PENGARUH KADAR Na-ALGINAT SEBAGAI MATRIKS MIKROSFER TERHADAP KARAKTERISTIK FISIK MIKROSFER DENGAN BAHAN AKTIF Bovine Serum Albumin (BSA)

CITRA DEWI ARUM PITALOKA, 051311133011 (2017) PENGARUH KADAR Na-ALGINAT SEBAGAI MATRIKS MIKROSFER TERHADAP KARAKTERISTIK FISIK MIKROSFER DENGAN BAHAN AKTIF Bovine Serum Albumin (BSA). Skripsi thesis, UNIVERSITAS AIRLANGGA.

[img]
Preview
Text (abstrak)
FF.F. 10-17 Pit p abstrak.pdf

Download (44kB) | Preview
[img] Text (fulltext)
FF.F. 10-17 Pit p fulltext.pdf
Restricted to Registered users only until 2 November 2020.

Download (1MB) | Request a copy
Official URL: http://lib.unair.ac.id

Abstract

The aim of this research was to investigate the effect of polymer on the physical characteristics BSA – loaded alginate microspheres. Microspheres prepared using ionotropic gelation with aerosolization technique. The concentration of sodium alginate as a matrix polymer was 1.5%, 2.0%, 2.5% and 1,5M CaCl2 was used as crosslinker. Microspheres were characterized for particle size, morphology, moisture content and yield value. Interaction between polymer and CaCl2 in microspheres was characterized by FT-IR and thermal analysis using DTA. As results, on the FT-IR spectra interaction confirmed by the shift of carbonyl group and the loss of guluronic wave number in the fingerprint area. In DTA thermogram shown a shift of melting point between the physical mixture and the formula at the temperature 190oC to 172 – 179oC. Spherical microspheres were shown with everage sizes from 2.20 – 2.84 μm, yield value was between 79.24 – 92.88% and moisture content was between 2.20 – 5.00% . Increase alginate concentration 0.5% in each formulas resulted an increase of particle size, moisture content and yield value.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F. 10-17 Pit p
Uncontrolled Keywords: aerosolization, BSA, microspheres, sodium alginate
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsEmail
CITRA DEWI ARUM PITALOKA, 051311133011UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorEsti Hendradi, Dra., Apt., M.Si., Ph.D,UNSPECIFIED
ContributorTutiek Purwanti, Dra., M.Si., Apt.UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 01 Nov 2017 16:07
Last Modified: 01 Nov 2017 16:07
URI: http://repository.unair.ac.id/id/eprint/65409
Sosial Share:

Actions (login required)

View Item View Item