PENGARUH RASIO LIPID PADAT SETIL PALMITAT DAN LIPID CAIR MEDIUM-CHAIN TRIGLYCERIDE (MCT) TERHADAP KARAKTERISTIK NLC CoQ10

JEANY RATNA PURWATRI, 051311133210 (2017) PENGARUH RASIO LIPID PADAT SETIL PALMITAT DAN LIPID CAIR MEDIUM-CHAIN TRIGLYCERIDE (MCT) TERHADAP KARAKTERISTIK NLC CoQ10. Skripsi thesis, Universitas Airlangga.

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Abstract

Coenzyme Q10 (CoQ10) is chemically unstable and easy to degrade when exposed to light. SLN and NLC are an alternative drug carrier systems that can be used. Compared to SLN, NLC shows a higher loading capacity for drugs and minimizing potential drug expulsion during storage. The aim of this study was to identify the characteristics of CoQ10 loaded NLC with different lipid ratio of cetyl palmitate (CP) and mediumchain triglyceride (MCT), such as 10:0; 9:1; 8:2; and 7:3. NLC was prepared using high shear hot homogenization method at 24000 rpm for 8 minutes. The products were characterized for pH, spreading property, particle size and entrapment efficiency (EE). The change in the ratio of MCT led to differences in EE. As MCT ratio increase up to 30% resulted the biggest %EE (35.30%).

Item Type: Thesis (Skripsi)
Additional Information: KKB KK2 FF.F.30/17 Pur p
Uncontrolled Keywords: Nanostructured lipid carriers, different lipid ratio cetyl palmitate-MCT, high shear homogenization, particle size, entrapment efficiency.
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
JEANY RATNA PURWATRI, 051311133210UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorNoorma Rosita, Dr. , M.Si., AptUNSPECIFIED
ContributorTristiana Erawati, Dr. , M.Si., AptUNSPECIFIED
Depositing User: Mr Binkol2 2
Date Deposited: 27 Dec 2017 20:03
Last Modified: 27 Dec 2017 20:03
URI: http://repository.unair.ac.id/id/eprint/65480
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