PENGARUH PERBEDAAN JENIS KOSURFAKTAN (POLOXAMER 188, LESITIN, PROPILEN GLIKOL) TERHADAP KARAKTERISTIK SLN-CoQ10

QURROTU A’YUNIN, 051311133246 (2017) PENGARUH PERBEDAAN JENIS KOSURFAKTAN (POLOXAMER 188, LESITIN, PROPILEN GLIKOL) TERHADAP KARAKTERISTIK SLN-CoQ10. Skripsi thesis, Universitas Airlangga.

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Abstract

Coenzyme Q10 (CoQ10) is an unstable chemical compound, especially to light, so it is easily to degrade. Therefore, a delivery system that can improve the stability of the CoQ10 is required. Solid lipid nanoparticles (SLN) is known to protect environment-sensitive molecules, and has controlled release characteristic. Characteristic of SLN can be seen from particle size and drug entrapment efficiency. The aim of this study was to determine the influence of different types of cosurfactants on SLN-CoQ10 characteristics. SLN-CoQ10 was prepared using high shear homogenization method at 24000 rpm for 2 minutes and 15000 rpm for a minute (4 cycle). There were four formulas of SLN-CoQ10 that were formulated with propylene glycol (A1), poloxamer 188 (B1), lecithin (C1) as cosurfactant and comparison without cosurfactant (D1). The particle size observation results of SLN-CoQ10 in formula A1, B1, C1, and D1 were respectively 556.1; 174.1; 220.4; and 556.8 nm. The smallest particle size was produced by the SLN-CoQ10 with poloxamer 188 (B1) as cosurfactant. While the percentage of SLN-CoQ10 entrapment efficiency in formula A1, B1, C1, and D1 were 32.47; 77.38; 19.77; and 16.09%. The greatest entrapment efficiency was produced by the SLN-CoQ10 with poloxamer 188 (B1) as cosurfactant. Based on the evaluation of SLN characteristics, the SLNCoQ10 preparation with poloxamer 188 as cosurfactant could be concluded to have the best characteristics because it had small particle size and large percentage of entrapment efficiency compared to SLN-CoQ10 with propylene glycol, lecithin as cosurfactant and without cosurfactant.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK2 FF.F.38/17 Aýu p
Uncontrolled Keywords: Solid lipid nanoparticles, coenzyme Q10, cosurfactant, particle size, entrapment efficiency
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
QURROTU A’YUNIN, 051311133246UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorNoorma Rosita, Dr. , Apt., M.SiUNSPECIFIED
ContributorEsti Hendradi, Dra. , Apt., M.Si., Ph.DUNSPECIFIED
Depositing User: Mr Binkol2 2
Date Deposited: 28 Dec 2017 17:16
Last Modified: 28 Dec 2017 17:16
URI: http://repository.unair.ac.id/id/eprint/65499
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