PENGARUH PEMBENTUKAN KOKRISTAL QUERCETIN - ASAM MALONAT YANG DIBUAT DENGAN SOLVENT-DROP GRINDING TERHADAP KELARUTAN DAN LAJU DISOLUSI

MUHAMMAD IQBAL, 051311133244 (2017) PENGARUH PEMBENTUKAN KOKRISTAL QUERCETIN - ASAM MALONAT YANG DIBUAT DENGAN SOLVENT-DROP GRINDING TERHADAP KELARUTAN DAN LAJU DISOLUSI. Skripsi thesis, Universitas Airlangga.

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Abstract

Quercetin (3, 3, 4, 5, 7 pentahydroxyflavone) is the compound of a flavonol, one of six subclasses of flavonoids and antioxidants known as high so that it can be used as a poten, chemo preventive barrier on breast cancer cells, colon, lung, and ovarian cancer cell growth. Quercetin is classified in the Biopharmaceutical Classification System (BCS) class II which means it has high permeability quercetin but solubility is low thereby affecting bioavaibility in the body. Cocrystal can be used as a method to increase solubility and dissolution rate of various poorly water soluble drug. This research aims to determine the influence of the formation of cocrystal by the method of solvent-drop grinding (SDG) for solubility and dissolution rate of quercetin. SDG is the development of grinding method by adding a little solvent in the process to improve the reaction of active ingredients and coformer. Cocrystal quercetin-malonic acid comparison will be made in 1:1 and 1:2 ratio. Solubility test results showing the solubility of quercetin increases with formation of cocrystal. The largest increase occurred in cocrystal quercetin-malonic acid ratio 1:2 with 1.5 times larger than the solubility of quercetin. Dissolution rate test results also showing dissolution cocrystal quercetin-malonic acid in ratio 1:2 have the largest efficiency better dissolution takes with 1.056 times quercetin, The results of the statistical analysis by the method of one way ANOVA followed by LSD test shows that the solubility and the rate has means better dissolution takes on the system are made. The conclusions of the research that has been done is the formation of cocrystal quercetiinmalonic acid can have affect the solubility and dissolution rate of quercetin.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK2 FF.F.46/17 Iqb p
Uncontrolled Keywords: quercetin, malonic acid, cocrystal, solubility, dissolution
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
MUHAMMAD IQBAL, 051311133244UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorDwi Setyawan, Dr. , S.Si.,M.Si.,AptUNSPECIFIED
ContributorHelmy Yusuf, M.Sc., Ph.DUNSPECIFIED
Depositing User: Mr Binkol2 2
Date Deposited: 28 Dec 2017 18:34
Last Modified: 28 Dec 2017 18:34
URI: http://repository.unair.ac.id/id/eprint/65524
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