Adi Prayitno and Widya Asmara and Ambar Mudigdo and Mandojo Rukmo, Prof. Dr., drg., SpKG., MSc. and Suhartono Taat Putra (2009) The expression of mitochondrial heat shock protein 10 in oral lesion with HPV positive. Folia Medica Indonesiana, 45 (2). ISSN 0303-7932

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Abstract

Hundreds of studies over the last 25 years have shown that stress contributes to many illnesses including cardiovascular disease, endocrine disease and cancer. Persistent infection with human papilloma-virus may play a central role in cervical carcinogenesis. Cancer may be defined as uncontrolled tissue growth in susceptible patient, with result from imbalance between cell division and program cell death (apoptosis). Psychosocial factors may influence cervical carcinogenesis via a psychoneuroimmunology pathway. Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide. Alcohol/tobacco consumption is the most important risk factor for this neoplasia; nevertheless, since 1983 it has been suggested that human papilloma viruses (HPV) have a role in HNSCC. The aim of this study is to know the protein expression especially heat shock protein 10 in oral lesions with HPV positive. Seventeen samples from many kind oral cavity lesions were collected from 1 January 2007 to 1 November 2007. DNA isolation and diagnose related HPV infections are made by Henk Schmits and/or Nigel McMillan and Nina Fowler method with some modifications. Protein isolation was doing with Vincent and Philippe method with some modifications and the SDS-PAGE protein electrophoresis was doing with 30mA for 6 hour. The result of this experiment was seen the band as 10kDa protein. And the conclusion is the expression oh heat shock protein 10 was up regulated in oral lesion with HPV positive. Certainly the apoptosis process was on.

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