PENGARUH JUMLAH ALGINAT TERHADAP KARAKTERISTIK FISIK MIKROPARTIKEL ANDROGRAFOLID-KITOSAN-ALGINAT (Dibuat dengan Gelasi Ionik-Pengeringan Beku)

SANDRA TUNGGADEWI, 051311133004 (2017) PENGARUH JUMLAH ALGINAT TERHADAP KARAKTERISTIK FISIK MIKROPARTIKEL ANDROGRAFOLID-KITOSAN-ALGINAT (Dibuat dengan Gelasi Ionik-Pengeringan Beku). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Andrographolide was a major component from Andrographis paniculata which had a wide potency as a medicine. However, Andrographolide has limited behavior such as low bioavailability and instability in acidic or alkaline extreme condition of gastrointestinal tract. Microparticle with combination of chitosan and alginate as it’s matrix had been studied to overcome these problem. The objective of this research was studying the effect of alginate concentration on physical characteristics and encapsulation efficiency of andrographolide-chitosan-alginate microparticles. The result showed that increasing alginate concentration will form non spherical particles with a rough surfaces. FTIR spectrum and DTA thermogram indicated polyelectrolyte complex between chitosan and alginate, also ionic bond between chitosan and TPP had formed. XRD diffractogram showed changes of andrographolide crystallinity. The entrapment efficiency of microparticle was increased at 0,5% alginate concentration. Further research about alginate concentration and aerosolization instrument needed for improving microparticle characteristics.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F. 17-17 Tun p
Uncontrolled Keywords: Andrographolide, Chitosan, Alginate, Freeze dry, Microparticle.
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
SANDRA TUNGGADEWI, 051311133004UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorRetno Sari, Dr., M.Sc., AptUNSPECIFIED
ContributorHelmy Yusuf, S.Si., M.Sc., Ph.D., AptUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 06 Nov 2017 19:35
Last Modified: 06 Nov 2017 19:35
URI: http://repository.unair.ac.id/id/eprint/65944
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