PENGARUH PEMBERIAN EKSTRAK KEMANGI (Ocimum sanctum L.) TERHADAP DERAJAT KERUSAKAN MUKOSA GASTER MENCIT (Mus musculus) YANG DIINDUKSI ASPIRIN

Zulfiatul Khiftiannisa’, 011311133085 (2017) PENGARUH PEMBERIAN EKSTRAK KEMANGI (Ocimum sanctum L.) TERHADAP DERAJAT KERUSAKAN MUKOSA GASTER MENCIT (Mus musculus) YANG DIINDUKSI ASPIRIN. Skripsi thesis, Universitas Airlangga.

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Abstract

Introduction: Long-term uses in high-dose therapy of aspirin causes gastric mucosal damage. Herbs which known has flavonoid compounds as gastroprotective is Ocimum sanctum L.. Objectives: This study aimed to determine the effect of extracts of Ocimum sanctum L. on the degree of mice (Mus musculus) gastric mucosal damage induced by aspirin. Material and methods: This experimental research used post-test only control group design. Thirty male mice average weight 20-30 grams were divided into 5 groups. Four groups (KP, P1, P2 and P3) were induced by aspirin 56 mg/kgBW for 7 days. One group (N) was administered with CMC Na 0,5% for 14 days. Group P1, P2, and P3 was administered with extract of Ocimum sanctum L. dosage 28, 42, and 56 mg/kgBW on day 8-14. All treatments were given per oral, once a day. The whole group was terminated on day 15, except KP which terminated on the 8th day. Gastric fundus was taken for Hematoxylin eosin staining (HE) and observed under a microscope, magnification of 400x in 5 visual fields to assess the degree of gastric mucosal damage by Esplugues & Whittle scoring system. Statistical analysis was done with Kruskal-Wallis and Mann-Whitney test. P value of <0.05 was considered statistically significant. Results: There was significant differences between the positive control group and treatment group 1 (p= 0.011). Positive control group shown 0% normal mucosa and dominated with third-degree damage while the treatment group 1 shown 20% normal mucosa and dominated with second-degree damage. Conclusion: It was only 28 mg/kgBW extract of Ocimum sanctum L. group which shown significant gastroprotective effect of gastric mucosal damage compared with positive control group.

Item Type: Thesis (Skripsi)
Additional Information: KKA KK FK.PD.68/17 Khi p
Uncontrolled Keywords: gastric mucosal damage, Ocimum sanctum, aspirin, gastroprotective, anti-ulcer
Subjects: R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: 01. Fakultas Kedokteran
Creators:
CreatorsNIM/NIDN
Zulfiatul Khiftiannisa’, 011311133085UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorDewi Ratna Sari, dr. M.SiUNSPECIFIED
ContributorArifa Mustika, Dr. , dr., M.SiUNSPECIFIED
Depositing User: Mr Binkol2 2
Date Deposited: 01 Jan 2018 22:45
Last Modified: 01 Jan 2018 22:45
URI: http://repository.unair.ac.id/id/eprint/66253
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