STUDI AKTIVITAS ANTIMALARIA IN VITRO TERHADAP PLASMODIUM FALCIPARUM PADA TANAMAN ARTOCARPUS SPP. YANG TUMBUH DI KEBUN RAYA BALIKPAPAN, KALIMANTAN TIMUR

RR. DIAJENG DEVITA KOESOEMAWARDHANI, 051311133165 (2017) STUDI AKTIVITAS ANTIMALARIA IN VITRO TERHADAP PLASMODIUM FALCIPARUM PADA TANAMAN ARTOCARPUS SPP. YANG TUMBUH DI KEBUN RAYA BALIKPAPAN, KALIMANTAN TIMUR. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Malaria is an infectious disease that still remain endemic in Indonesia, especially at the east part of Indonesia. The number of morbidity and mortality remains high due to the development of resistance by the lethal causative parasite, Plasmodium falciparum. Natural products are generally used in drug discovery and drug design, including antimalarial drugs. The aim of this study are to (1) identify the phytochemical constituent (2) measure the antimalarial activity of hexane, dichloromethane, and methanol extract of leaves and stem bark from several Artocarpus spp. plants, such as Artocarpus sericicarpus (pedalai), Artocarpus anisophyllus (mentawa), and Artocarpus dadah (dadak) from Moraceae, which obtained from the exploration of Balikpapan Botanical Garden. In this study, antimalarial assay was performed using enzymelinked immunosorbent assay (ELISA) with HRP2 measurement and microscopic method. The results showed that from 18 samples, 12 samples are active as antimalarial with inhibition percentage ranged from 50,9 ± 0,6% to 74,4 ± 2,3% . Its rich chemical substances are considered to take effect on antimalarial activity, such as polyphenols, flavonoids, terpenoids, and anthraquinone.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.FT. 53-17 Koe s
Uncontrolled Keywords: antimalarial, extract, Artocarpus sericicarpus, Artocarpus anisophyllus, Artocarpus dadah, Moraceae, inhibition percentage, ELISA, HRP2, microscopic, Balikpapan Botanical Garden.
Subjects: R Medicine > RC Internal medicine > RC31-1245 Internal medicine
R Medicine > RC Internal medicine > RC554-569.5 Personality disorders. Behavior problems Including sexual problems, drug abuse,suicide, child abuse
R Medicine > RM Therapeutics. Pharmacology
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:
CreatorsNIM/NIDN
RR. DIAJENG DEVITA KOESOEMAWARDHANI, 051311133165UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorAty Widyawaruyanti, Dr., MSi., Apt.,UNSPECIFIED
ContributorAchmad Fuad Hafid, Dr., MS., Apt.,UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 13 Nov 2017 20:16
Last Modified: 13 Nov 2017 20:16
URI: http://repository.unair.ac.id/id/eprint/66455
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