YANUAR EKA PUJIASTUTIK, NIM011514653003 (2017) PENGARUH EKSTRAK ETANOL KULIT BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) BERBAGAI DOSIS TERHADAP KADAR INTERLEUKIN-1β, EKSPRESI VASCULAR ENDOTHELIAL GROWTH FACTOR, DAN LUAS IMPLAN ENDOMETRIOSIS Penelitian Eksperimental Pada Hewan Coba Mencit Model Endometriosis. Thesis thesis, Universitas Airlangga.

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Abstract

Retrograde menstruationlead to I Kappa B Kinase (IKK) fosforilation in peritoneum macrophage and cause secretion of proinflammatory cytokine interleukin1β then stimulate endometriosis cell to produce Vascular Endothelial Growth Factor which lead to increasing of endometriosis lession seen as endometriosis implant area. Cytokine secretion was inhibited through prevention of NF-κB activation by dragon red fruit rind extract (Hylocereus polyrhizus). The aim of this reserach is to know the effect of dragon red fuit rind extract with 0,25; 0,5; and 1 mg/g bodyweight dosage toward IL-1β, VEGF expression and implant area in endometriosis mice model. The design of this experiment was randomized post test only control group design. Endometrios mice model were made in 14 days and split into five group, positive control group and treatment group after two week negative control group and postive control group were given Na-CMC 0,5% solution consequetively, and treatment group were given dragon red fruit rind extract with different dosage. Administration of dragon red fruit rind extract can decrease IL-1β, VEGF, and implant area in endometriosis mice model with the most effective 0,25 mg/g bodyweight dosage

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