PENGARUH PEMBERIAN MINUMAN BERENERGI JANGKA PANJANG TERHADAP FUNGSI GINJAL TIKUS PUTIH DENGAN MARKER TNFRSF6B

LUTHFIYANA RIF’ATUL ‘ALAM, 051211132015 (2016) PENGARUH PEMBERIAN MINUMAN BERENERGI JANGKA PANJANG TERHADAP FUNGSI GINJAL TIKUS PUTIH DENGAN MARKER TNFRSF6B. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Energy drink is one of food supplement that contained caffeine. Caffeine in energy drink is estimated as a risk factor of kidney function decline that lead to kidney disease. This study used 32 rats that divided by 4 groups as Control Negative (KN) administered aquadest, Control positive (KP) received caffeine solution, Higher Dosage Energy Drink (MBT) consumed energy drink at dose 7.7ml/kg BW, Lower Dosage Energy Drink (MBR) got 3.8ml/kg BW. Every group received the treathment twice a day during 60 days. Samples were collected at 0th, 40th, and 60th day of observation. Sample were collected include urine sample (creatinin and urine volume) and blood sample (creatinine and BUN). Kidney were taken after 60th day of observation by surgical operation for histopatholgy staining with HE and immunohistochemistry staining using TNFRSF6B. The results of this study showed that energy drink decreased urine creatinine significantly but this results not involved in decision making process. There were decreased urine volume even though not significant. Energy drink increased serum creatinine significantly but still on the normal range of creatinine serum (0.38-0.8mg/dL). There were decreasing trend of BUN although not significant. The histopathology analysis showed the differences in glomerular and tubular structure between negative control group and the treatment groups. Immunohistochemistry analysis showed that TNFRSF6B was expressed on tubular area in all of observaton groups (KN, KP, MBT, and MBR). The structural damage occured in treatment groups but creatinine serum still on the normal range means that kidney able to compromise and maintain their function during 60 days energy drink ingestion. Therefore, consuming energy drink for long period might increase creatinine serum but not contribute to the decrease of kidney’s function.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.FK.07-17 Ala p
Uncontrolled Keywords: energy drink, caffeine, kidney function, creatinine serum, TNFRSF6B
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmasi Klinis
Creators:
CreatorsNIM/NIDN
LUTHFIYANA RIF’ATUL ‘ALAM, 051211132015UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorMahardian Rahmadi, S.Si., M.Sc., Ph.D., AptUNSPECIFIED
ContributorSuharjono, Dr., MS., AptUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 05 Dec 2017 21:58
Last Modified: 05 Dec 2017 21:58
URI: http://repository.unair.ac.id/id/eprint/67360
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