EKSTRAK BUAH MAHKOTA DEWA (Phaleria macrocarpa) SEBAGAI PENURUN GULA DARAH PADA MENCIT YANG DI INDUKSI STREPTOZOTOCIN (STZ)

Larasati Citra Ayu Ramadhani, NIM011411131094 (2017) EKSTRAK BUAH MAHKOTA DEWA (Phaleria macrocarpa) SEBAGAI PENURUN GULA DARAH PADA MENCIT YANG DI INDUKSI STREPTOZOTOCIN (STZ). Skripsi thesis, Universitas Airlangga.

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Abstract

Background : Mahkota dewa (Phaleria macrocarpa) is one of Indonesian traditional medicine that contains alkaloids, flavonoids, resins, tannins and predicted to has a lowering effect on blood-glucose. Diabetes mellitus (DM) is a disease caused by insufficient insulin secretory by the pancreas or ineffective usage of insulin that produced by the body thus cause a hyperglycemia condition. Method : This was an experiment with posttest control group design. Samples were 30 mice, divided into three different groups (K, P1, and P2). Each groups were induced by multiple low-dose STZ. P1 treated with the extract of Phaleria macrocarpa , and P2 treated with metformin. Result : There was a reducing result of pretest posttest blood-glucose on P1 with the value of 176,143, while the value on P2 was 94,5. The independent-t test for the decrement on P1 and P2 were compared with independent-t test and has the pvalue of 0,277 (p>0,05) by means that there was no significant difference between the result of P1 and P2. Conclussion : The extract of mahkota dewa (Phaleria macrocarpa) has slightly more lowering effect towards the blood-glucose compared to metformin.

Item Type: Thesis (Skripsi)
Additional Information: KKA KK FK.PD 408/17 Ram e
Uncontrolled Keywords: Diabetes mellitus, hyperglycemia, mahkota dewa, Phaleria macrocarpa, streptozotocin induced, mice, metformin.
Subjects: R Medicine
Divisions: 01. Fakultas Kedokteran
Creators:
CreatorsNIM/NIDN
Larasati Citra Ayu Ramadhani, NIM011411131094NIM011411131094
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorSuhartati, Prof., Dr., , dr., MSUNSPECIFIED
Depositing User: Unnamed user with email indah.fatma@staf.unair.ac.id
Date Deposited: 20 Dec 2017 01:01
Last Modified: 20 Dec 2017 01:01
URI: http://repository.unair.ac.id/id/eprint/68462
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