UJI AKTIVITAS ANTIMALARIA EKSTRAK ETANOL KULIT BATANG PULAI (Alstonia scholaris) TERHADAP Plasmodium falciparum SECARA IN VITRO

Perthdyatama Syifaq Budiono, NIM011411131070 (2017) UJI AKTIVITAS ANTIMALARIA EKSTRAK ETANOL KULIT BATANG PULAI (Alstonia scholaris) TERHADAP Plasmodium falciparum SECARA IN VITRO. Skripsi thesis, Universitas Airlangga.

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Abstract

Malaria remains one of the endemic diseases in tropical countries, including Indonesia. Indonesia is one of the countries with the largest biodiversity, with many species, some used by society as traditional medicine. A. scholaris is one of Indonesian medicinal plants that are widely used as traditional malaria drugs, reported to contain secondary metabolite compounds such as alkaloids, flavonoids, steroids, and terpenoids.This study aims to evaluate the in vitro antimalarial activity of ethanolic extract of the stem barks of A. scholaris. The concentration of extract were 100; 10; 1.0; 0.1 and 0.001 μg /mL respectively, evaluate against P. falciparum. The blood smear was prepared from each test and stained with 10% Giemsa to calculate the percentage of parasitemia, growth of parasite and percentage of inhibition. Based on the percentage of inhibition, the IC50 was then probit analyzed by SPSS program. The analysis resulted in IC50 of 14.33 μg/mL that is categorized as modarate activity as antimalaria.

Item Type: Thesis (Skripsi)
Additional Information: KKA KK FK.PD.449/17 Bud u
Uncontrolled Keywords: Alstonia scholaris, Plasmodium falciparum 3D7, in vitro, antimalarial activity
Subjects: R Medicine > RC Internal medicine > RC109-216 Infectious and parasitic diseases
R Medicine > RM Therapeutics. Pharmacology > RM930-931 Rehabilitation therapy
Divisions: 01. Fakultas Kedokteran
Creators:
CreatorsNIM/NIDN
Perthdyatama Syifaq Budiono, NIM011411131070NIM011411131070
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorHeny Arwati, Dra., M.Sc., Ph.D.UNSPECIFIED
ContributorBudi Utomo, Dr., dr., M.Kes.UNSPECIFIED
Depositing User: Mrs Nadia Tsaurah
Date Deposited: 21 Dec 2017 00:03
Last Modified: 21 Dec 2017 00:03
URI: http://repository.unair.ac.id/id/eprint/68599
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