Afifah Zahra Dzakiyah, NIM011211132083 (2016) EFEKTIVITAS EKSTRAK KULIT BUAH MANGGIS DALAM PENURUNAN KADAR LDL DARAH TIKUS JANTAN GALUR WISTAR DENGAN PERLAKUAN HIPERLIPIDEMIA. Skripsi thesis, Universitas Airlangga.

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Abstract

Background: Atherosclerosis was caused by increase number of low density lipoprotein (LDL) in the blood plasm. This study aimed to examine the effectivity of Garcinia mangostana extract in decreasing number of LDL in rat with hiperlipid treatment. Materials and Methods : Giving appropriate amount of Hiperlipid diet which contain lard 28% composed by normal diet in 63 days to induced hiperlipidemia in rat. Rat with hiperlipid treatment treated with Garcinia mangostana extract in dose 300mg/kgBB by force feeding in fourteen days. Other groups with hiperlipid treatment treated with Garcinia mangostana extract in dose 600mg/kgBB by force feeding in fourteen days. Other group was a positive and negative control in hiperlipid treatment. Treatments are given orally once a day for fourteen days. Therapeutic effect of each treatments compared to control groups . Results : The result after 63 days was , negative control group K1 (15.67±3.445), positive control group K2 (16.67±2.160) treatment in dose 300mg/kgBB P1(16.83±2.401) and treatment in dose 600mg/kgBB P2 (17.80±2.049). The LDL level has no difference both between treated group and between treated and control grup. Conclusion: Garcinia mangostana extract treatment in fourteen days can’t decrease number of LDL level in rat with hyperlipidemic diet.

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