DITA NURLITA RAKHMA, 051514153021 (2018) PENGARUH RASIO LIPID TERHADAP STABILITAS FISIK DAN EFEKTIVITAS RESVERATROL DALAM SISTEM NANOSTRUCTURED LIPID CARRIER SEBAGAI KOSMETIKA ANTI-AGING(Studi dilakukan dengan Lipid Padat Gliseril Monostearat+Beeswax dan Lipid Cair Medium Chain Triglycerides). Thesis thesis, Universitas Airlangga.

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Abstract

Resveratrol is an antioxidant that has been developed as an anti aging cosmetics. However Resveratrol has limitation beacause of its poor solubility, so it is necessary to do the appropriate delivery system, one of which is lipid nanoparticles. In this study Resveratrol formulation was performed in NLC system with various ratio of binary solid lipids GMS+Beeswax and MCT as liquid lipid. The aims of this study are to determine the effect of lipid ratio in characteristic, physical stability and effectiveness of RSV loaded NLC. Based on the results, it was found that the difference of lipid ratio did not affect the lipid character shown by XRD and DSC data. But influenced the characteristics by increasing the liquid lipid, particle size and viscosity decrease significantly (p <0.05 ). In NLC-RSV 4 formula containing higher MCT indicates the presence of nanospoons phenomena, phase separation in the accelerated stability test and good penetration ability. Collagen density scoring data shown high collagen density scores of NLC-RSV 4 formula, whereas NLC-RSV 1 formula has moderate collagen density scores. These results are comparable when associated with the characteristics of each formula.

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