I Made Merdana and I Wayan Sudira and Ketut Budiasa and Samsuri (2018) EXTRACT ASHITABA (Angelica keiskei) IMPROVING THE IMMUNE RESPONSE IL-2Balb/C MICE VACCINATED WITH RABIES VACCINE. In: Prosiding/Proceeding: Musyawarah Nasional ke III Asosiasi Farmakologi dan Farmasi Veteriner Indonesia = 3rd National Conference of Indonesia Veterinary Pharmacy and Pharmacology Association. P4IPVI, Surabaya.

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Abstract

Ashitaba plant (Angelica keiskei) is native to Japan that has been developed in Indonesia, has many benefits,as a vegetable and as imonomudulator.This study aims to determine the ethanol extract effect of Ashitaba leaves (Angelica keiskei) to increase immune response IL-2, Balb/C mice were vaccinated with rabies vaccine. Treatment consisted of six points are without Ashitaba (control), giving a dose of 100 Ashitaba; 200; 300; 400, and 500 mg / kg orally for 21 days. Each treatment was repeated four times, so there are 24 units for researching. On the 28th day, do the vaccination with rabies vaccine to all groups of mice. On 49thday, the spleen was taken for viewing cultured lymphocytes producing cells. Variables observed are the levels of IL-2 levels of the lymphocyte.The results showed that the extract of Ashitaba can increase levels of IL-2 were significantly (P <0.05). Respectively, the average levels of interleukin-2 after treatment Ashitaba extract dose 0; 100; 200; 300; 400, and 500 mg/kg are 1,700; 3.919; 5.218; 8.875; 15.563. The conclusion,Ashitaba ethanol extract can improve the immune response of IL-2 and IFN-γ mice vaccinated with rabies vaccine.

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