CALCULATED WITHDRAWAL TIME BY LAZUARDI EQUATION METHOD

Mochamad Lazuardi and Tjuk Imam Restiadi and Bambang Hermanto (2018) CALCULATED WITHDRAWAL TIME BY LAZUARDI EQUATION METHOD. In: Prosiding/Proceeding: Musyawarah Nasional ke III Asosiasi Farmakologi dan Farmasi Veteriner Indonesia = 3rd National Conference of Indonesia Veterinary Pharmacy and Pharmacology Association. P4IPVI, Surabaya.

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Abstract

Residues of veterinary drug on consumption animals were giving hazardous for human health. This research aim was to determine calculated of withdrawal time by new concept namely LAZUARDI EQUATION FOR CALCULATE WITHDRAWAL TIME. The lazuardi postulate was using pharmacokinetics bases and analytical bases. The pharmacokinetics bases approximately taking parameter are dosing of the drug and elimination half-life. The analytical base approximately is taking the values of quantitation limit from instrument detection. Five adult male local Indonesia sheep at about 30 kg were giving clenbuterol HCl 0.02 mg from 0.75 mL of Ventipulmin® intravenously at single dose. The concentrations drug in plasma were assessed by HPLC reverse phase from serial sampling at time of 40., 60., 90., 120., 180., 240., 300., 360., 480., 500., 620., 740 min. Calculated of withdrawal time were using Lazuardi postulate. Result research apparently that means of elimination half-life and quantitation limit were obtained at 148.0658 min and 0.053 μg/mL. The conclusions of the research are determine of the drug by from lazuardi equation will be find out approximately at 1 d 5 h 28.32 min.

Item Type: Book Section
Uncontrolled Keywords: β2-agonist, Lazuardi equation for determined withdrawal time, HPLC reverse phase, pharmacokinetics of clenbuterol
Subjects: S Agriculture > SF Animal culture > SF600-1100 Veterinary medicine
S Agriculture > SF Animal culture > SF600-1100 Veterinary medicine > SF915-919.5 Veterinary pharmacology
Divisions: 06. Fakultas Kedokteran Hewan
Creators:
CreatorsEmail
Mochamad LazuardiUNSPECIFIED
Tjuk Imam RestiadiUNSPECIFIED
Bambang HermantoUNSPECIFIED
Depositing User: Ika Rudianto
Date Deposited: 04 Mar 2018 05:40
Last Modified: 04 Mar 2018 05:40
URI: http://repository.unair.ac.id/id/eprint/70346
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