FITRIKA WAHYU LISTARI, NIM011218016303 (2017) PERBEDAAN EFEKTIVITAS ANTARA TETES MATA SERUM AUTOLOGUS 20% DAN TETES MATA KOMBINASI SELULOSA DAN DEXTRAN 70 PADA SINDROMA MATA KERING DERAJAT 3 (Studi Eksperimental Klinis di RSUD Dr. Soetomo Surabaya). Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Purpose: This study evaluated the effectiveness of 20% autologous-serum eye drops versus unpreserved cellulose and dextran 70 in the treatment of patients with third grade dry-eye disease. Methods: Patients fulfilling inclusion criteria were randomized to either 2 weeks of 20% autologous serum eye drops or 2 weeks of unpreserved cellulose and dextran 70 eyedrops. Changes from baseline to 2-week values of ocular-surface-disease index (OSDI) ,corneal and conjunctival staining with fluorescein and rose bengal, tear-break-up time (TBUT), ferning test and were measured. Statistical analyses were carried out using T-Test and Mann-Withney Test. Results: Fifty eyes (15 patients) in the autologous-serum group and 16 eyes (16 patients) in the unpreserved cellulose and dextran 70 group completed the study. OSDI scores showed significant improvement in the autologous-serum group compared to that of the unpreserved cellulose and dextran 70 group at 2 weeks (p = 0.021). However, differences in staining scores, TBUT and ferning test were not significant. Conclusion: Use of both 20% autologous-serum eye drops and unpreserved cellulose and dextran 70 is safe and effective as single treatment for third grade dry-eye disease. However, dry-eye symptom significantly improved among patients in the autologous-serum group than those in the unpreserved cellulose and dextran 70 group.

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