PERUBAHAN KADAR sST2 SETELAH PEMBERIAN TERAPI KOMBINASI ACE- INHIBITORS DAN β-BLOCKERS PADA PASIEN INFARK MIOKARD AKUT (Penelitian Dilaksanakan di ICCU dan IRNA SMF Kardiologi dan Kedokteran Vaskular RSUD Dr. Soetomo Surabaya)

Khoirunnisa, 051515153016 (2017) PERUBAHAN KADAR sST2 SETELAH PEMBERIAN TERAPI KOMBINASI ACE- INHIBITORS DAN β-BLOCKERS PADA PASIEN INFARK MIOKARD AKUT (Penelitian Dilaksanakan di ICCU dan IRNA SMF Kardiologi dan Kedokteran Vaskular RSUD Dr. Soetomo Surabaya). Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

BACKGROUND: Suppression of Tumorigenicity (ST2) is a receptor for interleukin-33 (IL-33), excreted by living cell as a response to cellular damage due to mechanical stretch cardiomyocytes. Identification of this cardiomarker can be a sign of worsening clinical condition or as a prognostic and therapy evaluation factor in acute myocardial infarction (AMI) patients. Basic management in AMI is with balancing oxygen supply and demand. Combination therapy of ACE-Inhibitors and β-blockers work on modulating pathophysiology-related neurohormonal system and sympathic activity, as a consequence, the combination therapy will be able to lowered sST2 concentration in AMI. In Dr. Soetomo Teaching Hospital, combination therapy is frequently prescribed for inpatients. OBJECTIVES: to analyze the change of sST2 concentration after ACE-Inhibitors and β- blockers combination therapy in acute myocardial infarction inpatients in Dr. Soetomo Teaching Hospital. METHODS: this was a prospective observational study. Conducted in ICCU and Cardiovascular ward of Dr. Soetomo Teaching Hospital from July-December 2017. Blood samples from patients who met inclusion criteria were extracted before combination therapy as baseline and on the fourth day as post. sST2 were measured using Quantikine® ELISA: Human ST2/IL-33 R Immunoassay. This kit was using quantitative sandwich enzyme immunoassay techniqu. RESULTS: Total of 12 patients were included (11 male). After combination therapy, means of sST2 pre and sST2 post were significantly decreased, 492.7 ± 472.2 ng/mL to 46.9 ± 45.8 ng/mL (p<0.05). 15.5% decrease from baseline concentration showed clinically significant improvement in physiology condition. sST2 concentration lower than cut off 35 ng/mL showed better prognosis, three times lower in 30-days mortality. From 12 patients, sST2 concentration of 11 patients declined >15.5% (69.5%-98%) and there was 9 patients achieved concentration lower than cut off point. CONCLUSION: There was a significant decrease in sST2 cencentration after ACEInhibitors and β-blockers combination therapy in AMI patients.

Item Type: Thesis (Thesis)
Additional Information: KKB KK-2 TFK. 15-18 Kho p
Uncontrolled Keywords: sST2; Acute Myocardial Infarction; STEMI; ACE-inhibitors, β-blockers
Subjects: R Medicine > RC Internal medicine > RC666-701 Diseases of the circulatory (Cardiovascular) system
R Medicine > RM Therapeutics. Pharmacology
Divisions: 01. Fakultas Kedokteran > Mikrobiologi
Creators:
CreatorsNIM/NIDN
Khoirunnisa, 051515153016UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorBambang Subakti Z., S.Si, Apt., M. Clin PharmUNSPECIFIED
ContributorMuhammad Aminuddin, dr., Sp. JP (K), FIHA, FASCCUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 11 Mar 2018 17:32
Last Modified: 11 Mar 2018 17:48
URI: http://repository.unair.ac.id/id/eprint/70563
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