FATMA ROSIDA, NIM011218046301 (2017) PROFIL KADAR ANTIBODI ANTI PHENOLIC GLYCOLIPID-1 (PGL-1) PADA NARAKONTAK SERUMAH PASIEN KUSTA DI RSUD DR. SOETOMO SURABAYA. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background: Leprosy is a chronic infection caused by Mycobacterium leprae. It is still a challenging health problem in Indonesia with many new cases each year found in big city such as Surabaya. Leprosy occurs more commonly among household contacts. High titer of specific M. Leprae antibody found in blood without clinical symptoms is considered as subclinical leprosy. Early detection of this state plays an important role in elimination goal. Objective: to evaluate anti-PGL-1 antibody profiles in household contacts of multibacillary patients undergoing observation in Department of Dermatology and Venereology, Soetomo General Hospital- Surabaya. Materials and methods: We observed 62 household contacts of new patients and or within 3 months therapy. Blood were collected using filter paper and IgM anti- PGL-1 antibody were examined using ELISA. Results: Eighteen contacts (29%) tested positive for anti-PGL-1 antibodies with an average of 942,4±390,6 u/mL. The number of contacts based on the seropositivity rate was 17.7% for +1 and 11.3% for +2. Seropositive female was 22,6% and age-group of 18-36 years equal to 9.7%. Duration of contact-group of 6-16 years was 9,7%. Consanguinity with the patients was determined for 22,6%. Occupants more than 4 person in the household was 17.7% (973.9±428.2 u/ml). Conclusions: Household contacts at risk of developing clinical leprosy tend to have these characteristics : female, productive age, long-term contact, and inhabit crowded area.

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