PROFIL EKSPRESI p16INK4a DAN TIPE HUMAN PAPILLOMA VIRUS (HPV) PADA PASIEN KONDILOMA AKUMINATA WANITA di RSUD Dr SOETOMO SURABAYA

Afria Arista, 011318046303 (2017) PROFIL EKSPRESI p16INK4a DAN TIPE HUMAN PAPILLOMA VIRUS (HPV) PADA PASIEN KONDILOMA AKUMINATA WANITA di RSUD Dr SOETOMO SURABAYA. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background: Condyloma acuminata is a sexually transmitted disease caused by Human Papilloma Virus (HPV). High-risk HPV has the ability to develop into malignancy, whereas low-risk HPV is very rarely cause malignancy. The p16ink4a examination is used to detect potentially malignant HPV. Detection of HPV genotype by using PCR has a very high sensitivity. Purpose: This study is to determine the expression of p16INK4a in condyloma acuminata lesions with low risk HPV infection, high risk HPV infection, and multiple HPV infection infections Methods: This is cross sectional study conducted at Sexual Transmitted Infection Division of Outpatient Clinic, Dr. Soetomo General Hospital Surabaya. 13 patients with condyloma acuminata were examined genotyping by PCR and p16INK4a by immunohistochemistry. Sample was taken from the lession of condyloma acuminta by biopsy. Results: There were 5 patients with diffuse p16ink4a. The results of diffuse p16ink4a indicate that in these patients have the ability to develop into malignancy. Conclusions: Further study (cohort prospective) in condyloma acuminata patients with diffuse p16 features to determine the probability of malignancy in patients

Item Type: Thesis (Thesis)
Additional Information: KKA KK PPDS.IKK. 07-18 Ari p
Uncontrolled Keywords: Condyloma acuminata, genotyping, p16INK4a, pcr
Subjects: R Medicine > RG Gynecology and obstetrics > RG1-991 Gynecology and obstetrics
R Medicine > RG Gynecology and obstetrics > RG1-991 Gynecology and obstetrics > RG211-483 Abnormalities and diseases of the female genital organs
Divisions: 01. Fakultas Kedokteran > Ilmu Penyakit Kulit
Creators:
CreatorsNIM/NIDN
Afria Arista, 011318046303UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorDwi Murtiastutik, dr., SpKK(K)UNSPECIFIED
ContributorTrisniartami Setyaningrum, dr., SpKKUNSPECIFIED
ContributorGondo Mastutik, Dr., drh., M.Kes.UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 14 Mar 2018 20:22
Last Modified: 14 Mar 2018 20:22
URI: http://repository.unair.ac.id/id/eprint/70819
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