UJI AKTIVITAS ANALGESIK SENYAWA 4-NITROBENZOIL-3-ALILTIOUREA PADA MENCIT (Mus musculus) DENGAN METODE WRITHING TEST

WINDA PUTRI PRATAMA, 051211133005 (2018) UJI AKTIVITAS ANALGESIK SENYAWA 4-NITROBENZOIL-3-ALILTIOUREA PADA MENCIT (Mus musculus) DENGAN METODE WRITHING TEST. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Synthesis of 4-nitrobenzoyl-3-allylthiourea was accomplished by acylated allylthiourea with 4-nitrobenzoyl chloride. The acylation procedure based on Schotten-Baumann reaction modification triethylamine as a base and a catalyst. The percent yield of the product of synthesis was 28%. The purity of the compound was analyzed by Thin Layer Chromatography and melting point test. According to the UV-Vis and FT-IR spectra analysis, it showed that 4-nitrobenzoyl-3-allylthiourea was successfully synthesized. Analgesic activity of the compound was tested in mice (Mus musculus) using writhing test method with 0,6% acetic acid as the pain inducer. The doses of the 4-nitrobenzoyl-3-allylthiourea are 10 mg/KgBW, 20 mg/kgBW, and 40 mg/KgBW was given in mice by intraperitoneal injection. The result of ED50 for 4-nitrobenzoyl-3-allylthiourea is 12,5 mg/Kg body weight, for allylthiourea is 21,87 mg/Kg body weight, and for diclofenac natrium is 14,79 mg/Kg body weight. Statistically, the analgesic activity of 4-nitrobenzoyl-3-allylthiourea was higher compare with allylthiourea and diclofenac natrium.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.KF. 04-18 Pra u
Uncontrolled Keywords: analgesic activity test, 4-nitrobenzoyl-3-allylthiourea, writhing test method
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Kimia Farmasi
Creators:
CreatorsEmail
WINDA PUTRI PRATAMA, 051211133005UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorSiswandono, Prof. Dr., Apt., M.S.,UNSPECIFIED
ContributorTri Widiandani, Dr., S.Si., Sp.FRS., Apt.,UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 18 Mar 2018 17:06
Last Modified: 18 Mar 2018 17:06
URI: http://repository.unair.ac.id/id/eprint/70922
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