VALIDASI METODE FLAME ATOMIC ABSORPTION SPECTROPHOTOMETRY (FAAS) UNTUK PENETAPAN KADAR MINERAL (Cu, Fe, dan Mn) DALAM SEDIAAN KAPSUL MULTIVITAMINMINERAL

SURYO KUSUMA PRADANA, 051311133169 (2017) VALIDASI METODE FLAME ATOMIC ABSORPTION SPECTROPHOTOMETRY (FAAS) UNTUK PENETAPAN KADAR MINERAL (Cu, Fe, dan Mn) DALAM SEDIAAN KAPSUL MULTIVITAMINMINERAL. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The purpose of this present study is to validate the Flame Atomic Absorption Spectrometry (FAAS) for the determination of minerals contained in the multivitamin-mineral capsule such as Cu (copper), Fe (iron), and Mn (manganese). The sample is destructed through destruction process of dry ashing (550 ± 20° C for 2 hours until in ashes form) then continued to wet ashing by using mixture of 6 M HCl and concentrated HNO3 (25:1). The validation of the method comprises the selectivity, linearity, limit of detection (LOD, limit of quantification (LOQ), precision, and accuracy. The proposed method has concentration ranges of 0.49 – 1.99 μg/ml for Cu, 1.99 – 9.99 μg/ml for Fe, and 0.50 – 2.01 μg/ml for Mn. The correlation coefficient (r) obtained for each linearity equations are higher than 0.999 with the relative process standard deviation value (Vxo) is not more than 5%. LOD are found to be 4.8×10-3 μg/ml for Cu, 6.2×10-2 μg/ml for Fe, and 1.7×10-2 μg/ml for Mn, meanwhile the LOQ are 0.01 μg/ml for Cu, 0.1865 μg/ml for Fe, and 0.05 μg/ml for Mn. The method was successfully applied for the determination of the minerals e.g. Cu, Fe, and Mn in Multivitamin-mineral capsule dosage form.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.KF. 02-18 Pra v
Uncontrolled Keywords: Method validation, FAAS, copper, iron, manganese, multivitamin-mineral, capsule dosage form.
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Kimia Farmasi
Creators:
CreatorsNIM/NIDN
SURYO KUSUMA PRADANA, 051311133169UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorMoch. Yuwono, Prof. Dr. rer. nat. H., MS., Apt.UNSPECIFIED
ContributorRiesta Primaharinastiti,, Dr., SSi., MSi.UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 18 Mar 2018 17:34
Last Modified: 18 Mar 2018 17:34
URI: http://repository.unair.ac.id/id/eprint/70924
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