The Effect of Cisdiamminedichloroplatinum (II) Treatment on Development of Follicles Rat (Rattus Novergicus) Ovaries

Hertiwirani, Alfina and Srianto, Pudji and Wurlina, - and Madyawati, Sri Pantja and Widjiati, - (2012) The Effect of Cisdiamminedichloroplatinum (II) Treatment on Development of Follicles Rat (Rattus Novergicus) Ovaries. Proceeding International Seminar : Strategy To Manage Bio-Eco-Health System for Stabilizing Animal Health & Productivity to Support Public Health. pp. 190-191. ISSN 978-602-8967-69-3

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Abstract

This aims of the research was to determine the effect of Cis diammine dichloro platinum (Il) toward ovarian histologic overview (the number of primary follicle, seconday follicle, tertiary follicle, Graafian) in rat (Rattus novergicus) as a model. The samples were 32 Rat (Rattus novergicus) randomly devided into two group, control and treatment group. At the estrus phase, the control group was injected by NaCl 0,9% IP, and the treatment group was injected by Cisdiammine dichloroplatinum (Il) 5 mg/kg bw IP. The rat were slaughtered at the 7th day, oophorectomy was performed, continued with hematoxylin eosin staining for the amount of follicles examination. The result of the research indicated that the amount of primary, secondary, tertiary, de Graaf, and atrethic follicle of treatment group were 8.01 ± 0.84, 3.71 ± 1.25, 2.23 ±0.41, 1.98 ± 0.33, and 1.54 ± 0.41 respectively. It were significantly lower (p<0,05) compared to control group 9.12 ± 0.96, 5.63 ± 0.98, 4.70 ± 1.53, 2.26 ± 0.75, and 1.88 ± 0.37 respectively. It could be concluded that the injection of Cisdiamminedichloroplatinum (Il) in the rat (Rattus novergicus) as a model cause a decrease of the number of follicles

Item Type: Article
Uncontrolled Keywords: Cisdiamminedichloroplatinum (Il), Rattus norvegicus and follicles
Subjects: S Agriculture > SF Animal culture > SF600-1100 Veterinary medicine > Including veterinary genetics, ethology, anatomy, physiology, embryology, pathology
Divisions: 06. Fakultas Kedokteran Hewan > Anatomi Veteriner
Creators:
CreatorsEmail
Hertiwirani, AlfinaUNSPECIFIED
Srianto, PudjiUNSPECIFIED
Wurlina, -UNSPECIFIED
Madyawati, Sri PantjaUNSPECIFIED
Widjiati, -UNSPECIFIED
Depositing User: Nn Erna Dwi Indriyani
Date Deposited: 23 May 2018 20:07
Last Modified: 03 Aug 2018 00:00
URI: http://repository.unair.ac.id/id/eprint/71929
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