Red fruit oil increases trophoblast cell and decreases caspase -9 expression in placenta of lead exposed mice

Sumarsono, Portia and Widjiati and Susilowati, Suherni (2016) Red fruit oil increases trophoblast cell and decreases caspase -9 expression in placenta of lead exposed mice. Universa Medicina, 35 (2). pp. 110-118. ISSN 1907-3062

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Abstract

BACKGROUND Lead is able to pass through the placental barrier and interfere with fetal development. Red fruit has high antioxidant activity, due to carotenoids (pro-vitamin A), tocopherols (vitamin E) and unsaturated fatty acids. This study aims to examine the effect of red fruit oil towards placenta in pregnant mice before lead exposure. METHODS This was a laboratory experimental post test only study, using 20 pregnant mice (Mus musculus) that were randomized into five groups. The negative control group was not exposed to lead; intervention group 0 (P0) was exposed to lead at 0.011 mg/20 g BW/day on days 6-15 of gestation. The intervention groups P1-P3 were given red fruit orally at 0.3 mL/20 g BW/day, 0.8 mL/20 g BW/day, 0.9 mL/20 g BW/day, respectively, before lead exposure. Normal trophoblast cell count and caspase-9 expression of trophoblasts were calculated. One-way ANOVA, Kruskal-Wallis and Mann Whitney tests were used to analyze the data. RESULTS The intervention groups P2 and P3 given red fruit at 0.8 mL/20 g BW/day and 0.9 mL/20 g BW/day showed a significant increase in normal trophoblast cell count of 88.2% (p=0.024) and a decrease in caspase-9 expression of 70.8% compared with P0 to which was not given red fruit (p=0.020). CONCLUSION Red fruit increased normal trophoblast cell count by 88.2% and decreased caspase-9 expression by 70.8% in pregnant mice before lead exposure. It should be noted that red fuit may prevent oxidative damage to cells

Item Type: Article
Uncontrolled Keywords: Lead; red fruit; caspase-9; trophoblasts; pregnant mice
Subjects: S Agriculture > SF Animal culture > SF600-1100 Veterinary medicine
S Agriculture > SF Animal culture > SF600-1100 Veterinary medicine > Including veterinary genetics, ethology, anatomy, physiology, embryology, pathology
Divisions: 06. Fakultas Kedokteran Hewan > Anatomi Veteriner
Creators:
CreatorsNIM/NIDN
Sumarsono, PortiaUNSPECIFIED
WidjiatiUNSPECIFIED
Susilowati, SuherniUNSPECIFIED
Depositing User: Nn Erna Dwi Indriyani
Date Deposited: 23 May 2018 21:27
Last Modified: 01 Aug 2018 17:55
URI: http://repository.unair.ac.id/id/eprint/72284
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