Rini Devijanti Ridwan, drg.,MKes and Retno Indrawati (2014) A.actinomycetemcomitans adhesi protein increasing IL-8 titre in heart of wistar rat with aggressive periodontitis. Dentofasial Jurnal Kedokteran Gigi Makasar, 13 (2). pp. 74-79. ISSN 1412-8926

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Abstract

Cardiovascular and periodontal diseases are common inflammatory conditions in the human population. Tlymphocytes participate in the pathogenesis and inflammatory events of atherosclerosis. These immune cells enter the inflamed artery wall and join macrophages via a number of interferon-c-inducible chemokines. Chemokines (IL-8), cytokines, and growth factors also participate in this process. The interaction between interleukin- 8 and its receptor, CXCR2, can also contribute to lesion formation in mice. The main causes of aggressive periodontitis is Actinobacillus actinomycetemcomitans. Previous studies have proven that adhesin protein with 24 kDa molecular weight from A.actinomycetemcomitans is a specific adhesin, this adhesin proteins play a role in the adhesion process on host. this kind adhesion in the epithelial attachment would lead to colonization and invasion of A.actinomycetemcomitans that will stimulate the host immune response. This study aimed to analyze the influence of induction 24 kDa A.actinomycetemcomitans adhesin protein to the titre of IL-8 in heart of Wistar rat with aggressive periodontitis using Elisa method to measure and analyze the titre of IL-8. After analyzed with analysis of variance, showed significant differences of IL-8 titre in the control group and the group with the induction by A.actinomycetemcomitans, A.actinomycetemcomitans plus 24 kDa A.actinomycetemcomitans adhesin protein, and only with 24 kDa A.actinomycetemcomitans adhesin protein. It can be concluded that A.actinomycetemcomitans adhesin protein with 24 kDa molecular weight has a role in increasing of IL-8 titre in heart wistar rat with aggressive periodontitis. Keywords: Actinobacillus actinomycetemcomitans, adhesin proteins, IL-8 titre, heart, aggressive periodontitis

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