Ernie Maduratna, Setiawatie and Sri Wigati Mardi, Mulyani (2012) Ekspresi caspase 9 pada kultur Bone Marrow Stem Cell (BMSCs) dengan kondisi hipoksia. Periodontic Journal, 4 (2). ISSN 2085-711X.

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Abstract

Background : Bone marrow stem cells (BMSCs) have demonstrated potential for periodontal regenerative medicine strategies. Hipoxia condition was necessary to support bone marrow stem cell viability. Therefore, it is necessary to prove scientifically what the influence hypoxia precondition to the evidence of apoptosis on BMSCs culture. Objective.The purpose of this study to explore the effects of hypoxia on BMSCs on caspase 9 expression . Methods. Research design used experimental laboratories. The isolation of stem cells was made culturing the mesenchymal stem cells derived from crista illiaca of the bone marrow from male rabbits. Stem cell culture was performed in hypoxic conditions (O2 1%,3%,5%) and measured caspase -9 expression using RT-PCR . Result. This hypoxic precondition in the culture of Bone Marrow Mesenchymal Stem Cells decrease caspase 9 expression. Conclusion : Hypoxic precondition can reduce apoptosis in the culture of Bone Marrow Mesenchymal Stem Cells.

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