Physicochemical Characterization and In Vitro Dissolution Test of Quercetin-Succinic Acid Cocrystals Prepared Using Solvent Evaporation

Setyawan, Dwi and Oktavia, Indah Puji and Farizka, Rizka and Sari, Retno (2017) Physicochemical Characterization and In Vitro Dissolution Test of Quercetin-Succinic Acid Cocrystals Prepared Using Solvent Evaporation. Turkish Journal of Pharmaceutical Sciences, 14 (3). pp. 280-284.

[img]
Preview
Text (FULLTEXT)
C-2 Artikel.pdf

Download (4MB) | Preview
[img]
Preview
Text (Reviewer)
C-2 Validasi dan Peer Reviewer.pdf

Download (1MB) | Preview

Abstract

Objectives: Quercetin is one of the flavonoids with a polyhydroxyaromatic structure. Quercetin has been proposed to exhibit a bioWactivity against oxidative stress. However, quercetin has poor solubility in aqueous media. The purpose of this study was to investigate the physicochemical properties and dissolution rates of quercetin-succinic acid co-crystals. Materials and Methods: The quercetin-succinic acid co-crystals were prepared in 1:1 molar ratio using solvent evaporation. X-ray diffraction, differential thermal analysis, infrared spectroscopy, and scanning electron microscopy were performed to determine the physicochemical properties of quercetin-succinic acid co-crystals. Dissolution was studied in medium citrate buffer with 2% SLS for 60 min using USP II (paddle) apparatus at 100 rpm and 37°C. Results: Based on diffractogram, thermogram, infrared spectrum, and microscopic capture, the physicochemical properties of quercetin-succinic acid co-crystals showed difference to those of quercetin. In addition, the in vitro dissolution test showed that the dissolution profile of co-crystals was significantly higher than pure quercetin. Conclusion: This study suggests that the formation of quercetin-succinic acid co-crystals using solvent evaporation enhanced the physicochemical properties and dissolution rate of quercetin. Key words: Characterization, dissolution, co-crystal, quercetin, succinic acid, solvent evaporation

Item Type: Article
Uncontrolled Keywords: Characterization, dissolution, co-crystal, quercetin, succinic acid, solvent evaporation
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM/NIDN
Setyawan, Dwidwisetyawan-90@ff.unair.ac.id
Oktavia, Indah PujiUNSPECIFIED
Farizka, RizkaUNSPECIFIED
Sari, Retnoretno-s@ff.unair.ac.id
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 19 Nov 2018 15:57
Last Modified: 19 Nov 2018 15:57
URI: http://repository.unair.ac.id/id/eprint/73323
Sosial Share:

Actions (login required)

View Item View Item