Solvent Concentration Effect on Powder X-Ray Diffraction And Dissolution Profiles Of Acyclovir-Nicotinamide Cocrystals

Dwi Setyawan and Siswandono and Agnes Nuniek Winantari and Kuni Zu’aimah (2017) Solvent Concentration Effect on Powder X-Ray Diffraction And Dissolution Profiles Of Acyclovir-Nicotinamide Cocrystals. International Journal of Drug Delivery Technology, 7 (4).

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Abstract

Objective : Acyclovir (ACV) is well-known antiviral agent that has absorption problem, mainly due to its poor solubility in water and oral bioavailability. To improve acyclovir physical properties, especially dissolution properties, acyclovir- nicotinamide(NCT) cocrystal was formed. Methods : ACV-NCT cocrystal was prepared using slurry method using ethanol as solvent with different concentration. The ACV-NCT cocrystal from each sample groups was characterized using powder X-ray diffraction (PXRD), and then dissolution properties evaluated. Results : Each ACV-NCT cocrystals prepared from slurry method with different ethanol concentrations have different PXRD profile. Dissolution analysis (ED 15 ) showed that ACV-NCT cocrystallization using slurry methods with 10,0 ml/g as ethanol concentration significantly increase ED 15 values compared to acyclovir and acyclovir-nicotinamide physical mixture (α=0,05). Conclusion : ACV-NCT cocrystal successfully formed using slurry method with 10,0 ml/g as optimal ethanol concentration. Keywords: Cocrystal, Acyclovir, Nicotinamide, Slurry method.

Item Type: Article
Uncontrolled Keywords: Cocrystal, Acyclovir, Nicotinamide, Slurry method.
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM/NIDN
Dwi Setyawandwisetyawan-90@ff.unair.ac.id
Siswandonosiswandono@ff.unair.ac.id
Agnes Nuniek WinantariUNSPECIFIED
Kuni Zu’aimahUNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 21 Nov 2018 10:30
Last Modified: 13 Dec 2018 09:33
URI: http://repository.unair.ac.id/id/eprint/73325
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