PEG 8000 increases solubility and dissolution rate of quercetin in solid dispersion system

Dwi Setyawan and Setiawardani Febrianti and Amrullah Zainul and Retno Sari (2017) PEG 8000 increases solubility and dissolution rate of quercetin in solid dispersion system. Marmara Journal of Pharmaceutical Sciences, 22 (2). ISSN 2630-6344

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Abstract

ABSTRACT: The aim of this study was to examine the physical characteristics, solubility, and in vitro dissolution profile of quercetin-PEG 8000 solid dispersion prepared by melting method. Solid dispersion was prepared by melting method with various ratios of quercetin and PEG 8000 (1:1; 1:2; 1:3). The solid dispersion was characterized using differential thermal analyzer (DTA), powder X-ray diffraction (PXRD), scanning electron microscope (SEM), and fourier transform infrared spectroscopy (FTIR). The solubility and in vitro dissolution of quercetin-PEG 8000 solid dispersion were evaluated and compared to physical mixture and pure quercetin. The solid dispersion of quercetin-PEG 8000 has lower melting point and crystal peak intensity compared to pure quercetin and physical mixture. The infrared spectra of solid dispersions and physical mixtures indicated the occurrence of physical interactions that involved weak bonding forces such as the hydrogen bond between quercetin functional groups and O-H group. The solubility and the dissolution rate enhanced in accordance with increasing of PEG 8000 amount. KEYWORDS: Quercetin; PEG 8000; solid dispersion; solubility; dissolution rate.

Item Type: Article
Uncontrolled Keywords: Quercetin; PEG 8000; solid dispersion; solubility; dissolution rate.
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM/NIDN
Dwi Setyawandwisetyawan-90@ff.unair.ac.id
Setiawardani FebriantiUNSPECIFIED
Amrullah ZainulUNSPECIFIED
Retno Sariretno-s@ff.unair.ac.id
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 21 Nov 2018 10:36
Last Modified: 24 Jun 2019 02:01
URI: http://repository.unair.ac.id/id/eprint/73326
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