Improvement In Vitro Dissolution Rate of Quercetin Using Cocrystallization of Quercetin-Malonic Acid

Setyawan, Dwi and Adhi, Sukma and Zainul, Ahmad and Dwi Lestari, Maria Lucia Ardhani (2018) Improvement In Vitro Dissolution Rate of Quercetin Using Cocrystallization of Quercetin-Malonic Acid. Indonesian Journal of Chemistry, 18 (3).

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Official URL: https://jurnal.ugm.ac.id/ijc/article/view/28511/20...

Abstract

The aim of the study was to improve the in-vitro dissolution rate of quercetin (Qu) using cocrystallization of quercetin. Cocrystals of quercetin (Co Qu) were produced with malonic acid (Ma) as coformer at ratio 1:2 using solvent evaporation method. Cocrystals quercetin-malonic acid (Co Qu-Ma) was characterized using Differential Thermal Analysis (DTA), Powder X-Ray Diffraction (PXRD), Scanning Electron Microscope (SEM), and Fourier Transforms Infrared Spectrophotometer (FTIR) and in-vitro dissolution study. A new endothermic peak at 277.9 °C was shown from the thermogram. Diffractogram of Co Qu-Ma showed a new diffraction peak at 2θ 9.81, 12.99, and 19.80°. Microphotograph showed that Qu and Ma exhibited a columnar-shaped and a pebble-shaped crystal, respectively, and FTIR wavenumber of O-H functional group of quercetin was shifted from its original position at 3411 to 3428 cm-1 in the physical mixture (pm) of Qu-Ma and 3418 cm-1 in Co Qu-Ma, respectively. The physicochemical characterizations using DTA, PXRD, SEM and FTIR indicated that Co Qu-Ma were successfully obtained through solvent evaporation method. The in-vitro dissolution rate of Co Qu-Ma was 95.30% at 60 min. Cocrystals ffectively increased dissolution rate and dissolution efficiency in comparison to the pure quercetin and physical mixture of quercetin-malonic acid. Keywords: quercetin; malonic acid; cocrystal; in-vitro dissolution

Item Type: Article
Uncontrolled Keywords: quercetin; malonic acid; cocrystal; in-vitro dissolution
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
Setyawan, Dwidwisetyawan-90@ff.unair.ac.id
Adhi, SukmaUNSPECIFIED
Zainul, AhmadUNSPECIFIED
Dwi Lestari, Maria Lucia Ardhanimaria-lestari@ff.unair.ac.id
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 21 Nov 2018 10:48
Last Modified: 21 Nov 2018 10:48
URI: http://repository.unair.ac.id/id/eprint/73328
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