PROFIL WNT1, Β-CATENIN, SEL PUNCA MELANOSIT DAN MELANOSIT FOLIKEL RAMBUT PADA REPIGMENTASI PERIFOLIKULER VITILIGO DENGAN PEMBERIAN NARROW BAND - ULTRAVIOLET B

DIAN ARDIANA, 011217017311 (2018) PROFIL WNT1, Β-CATENIN, SEL PUNCA MELANOSIT DAN MELANOSIT FOLIKEL RAMBUT PADA REPIGMENTASI PERIFOLIKULER VITILIGO DENGAN PEMBERIAN NARROW BAND - ULTRAVIOLET B. Disertasi thesis, Universitas Airlangga.

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Abstract

Background : Melanocyte stem cells (MelSCs) have been identified in the lower permanent portion of hair follicle and associated with perifollicular repigmentation pattern of vitiligo after Narrow Band-Ultraviolet B (NB-UVB) therapy. Wnt1 and β- catenin have been associated with UVB induced pigmentation in mouse and hyperpigmented lesion commonly seen on sun-exposed areas. The increase of MelSCs in these two conditions suggested the role of Wnt1 in MelSCs differentiation, which increases the number of melanocytes. Purpose : To explain the profile of hair follicle Wnt1, β-catenin, MelSCs and melanocytes in NB-UVB induced vitiligo perifollicular repigmentation. Methods : This clinical pre-experimental study used one group pre test-post test design. The dose of 390 mJ/cm2 DermaPalTM Daavlin NB-UVB was given twice a week for 2 months to 18 vitiligo patients. Biopsy was undertaken in vitiligo areas involving hair follicle before and after therapy and was assessed by immunohistochemistry technique. Data was analyzed using SPSS. Results : There was a significant difference (p<0.05) of vitiligo area size, the number of cells expressing Wnt1, MelSCs, MelSCs expressing β-catenin, MelSCs proliferation, melanocytes, also melanoblast and melanocytes proliferation in hair follicle before and after NB-UVB irradiation. Conclusion : There was a change in the profile of hair follicle Wnt1, β-catenin, MelSCs and melanocytes in vitiligo perifollicular areas before and after NB-UVB therapy. The finding of increment of hair follicle Wnt1 and β-catenin expression after NB-UVB therapy became the novelty of this study and it could be used for further research in perifollicular repigmentation mechanism.

Item Type: Thesis (Disertasi)
Additional Information: KKA KK Dis. K. 32-18 Ard p
Uncontrolled Keywords: melanocyte stem cells, NB-UVB, perifollicular repigmentation, vitiligo Wnt1/β-catenin
Subjects: R Medicine > RL Dermatology
Divisions: 01. Fakultas Kedokteran
Creators:
CreatorsEmail
DIAN ARDIANA, 011217017311UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorIndropo Agusni, Prof. Dr., dr., Sp. KK (K), FINSDV, FAADV.UNSPECIFIED
ContributorCita Rosita Prakoeswa, Dr., dr., Sp. KK (K), FINSDV, FAADV.UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 04 Oct 2018 12:38
Last Modified: 04 Oct 2018 12:38
URI: http://repository.unair.ac.id/id/eprint/74355
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