A. MU'THI ANDY SURYADI, 051414153015 (2018) MODIFIKASI STRUKTUR PINOSTROBIN DARI TEMU KUNCI (Boesenbergia pandurata Roxb. Schlect) DAN HUBUNGAN KUANTITATIF STRUKTUR AKTIVITAS ANALGESIK TERHADAP MENCIT (Mus musculus). Thesis thesis, Universitas Airlangga.

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Abstract

Temu kunci (Boesenbergia pandurate Roxb. Schlecht) is one of the ginger plants that contain pinostrobin. It determined as an anti-inflammatory and analgesic activities through inhibition of COX-2 enzymes. The objective of this research was to obtain pinostrobin from Boesenbergia pandurata Roxb. Schlect and pinostrobin derivatives of acylation reactions between pinostrobin and acyl chloride derivatives. The structure modifications of pinostrobin were obtained by Schotten-Baumann method through nucleophilic substitution reactions between pinostrobin and acyl chloride derivatives. The investigation of structure modifications of pinostrobin from this plant has demonstrated the present of pinostrobin acetate, pinostrobin propionate, pinostrobin butyrate, and pinostrobin pentanoate based on the spectrometric analysis such as IR, NMR, and MS. All compound were evaluate for their analgesic activity by writhing test models on mice (Mus musculus). The test showed pinostrobin derivates possessed higher analgesic activity compared to pinostrobin. QSAR studies showed the best correlation between electronic parameter (Etotal and RS) and steric parameter (MR).

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