SINTESIS SENYAWA 3-(BENZILIDENAMINO)-2-(2-KLOROFENIL) KUINAZOLIN-4(3H)-ON TERSUBSTITUSI DENGAN METODE PEMANASAN KONVENSIONAL DAN IRADIASI GELOMBANG MIKRO

LUTHFI AHMAD MUCHLASHI, 051514153003 (2018) SINTESIS SENYAWA 3-(BENZILIDENAMINO)-2-(2-KLOROFENIL) KUINAZOLIN-4(3H)-ON TERSUBSTITUSI DENGAN METODE PEMANASAN KONVENSIONAL DAN IRADIASI GELOMBANG MIKRO. Thesis thesis, Universitas Airlangga.

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Abstract

A series of quinazoline derivatives were synthesized and characterized by IR, 1H-NMR, and 13C-NMR. We compared methodology for the synthesis of substituted 3-(benzylideneamino)-2-(2-chlorophenyl)quinazolin-4(3H)-one using conventional heating with microwave irradiation. It aims to find out if microwaveassisted synthesis of substitued 3-(benzylideneamino)-2-(2-chlorophenyl) quinazolin-4(3H)-one adds any advantage or not. The results suggest that microwave-assisted synthesis proved much more convenient and dramatically cutting down reaction times. Subsequently, by comparing total reaction time of four different substituted 3-(benzylideneamino)-2-(2-chlorophenyl)quinazolin- 4(3H)-one, It was found that electron donating presents in benzaldehyde is shortening the reaction times and electron withdrawing group presents is extending the reaction times. These findings described that the type of benzaldehyde substituents have role in these synthesis.

Item Type: Thesis (Thesis)
Additional Information: KKB KK-2 TF. 24-18 Muc s
Uncontrolled Keywords: quinazoline, conventional synthesis, microwave-assisted synthesis
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
LUTHFI AHMAD MUCHLASHI, 051514153003UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorTutuk Budiati, Prof. Dr. MS., AptUNSPECIFIED
ContributorHadi Poerwono, Drs., MSc., PhD., AptUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 01 Nov 2018 16:43
Last Modified: 01 Nov 2018 16:43
URI: http://repository.unair.ac.id/id/eprint/75254
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