In vivo Antimalarial Activity of Andrographis paniculata Tablets

Widyawaruyanti, Aty and Asrory, Muhammad and Ekasari, Wiwied and Setiawan, Dwi and Radjaram, Achmad and Tumewu, Lidya and Hafid, Achmad Fuad (2012) In vivo Antimalarial Activity of Andrographis paniculata Tablets. Procedia Chemistry, 13. pp. 101-104. ISSN 1876-6196

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Official URL: https://www.sciencedirect.com/science/article/pii/...

Abstract

The formulation of three phytopharmaceutical products of Andrographispaniculata fractions (AP fraction A and B) containing diterpene lactones as an active substance were developed and their antimalarial activities against Plasmodium bergheihas been examined. In vivo antimalarial assay on P. berghei infected mice was carried out by oral administration,twice a dayfor four consecutive days of the AP fractions product, which were Tablet I : wet granulated formula of AP fraction A; Tablet II : wet granulated formula of AP fraction B; Tablet III : solid dispersion formula of AP fraction B.. The results revealed that three phytopharmaceutical products of A.paniculata were inhibited parasite’s growth with inhibition range of 70.15% to 80.35%. There was no significant difference of antimalarial activities between Tablet II and III, meanwhile there was significant difference among Tablet I with Tablet II and Tablet III.It was concluded that antimalarial activity depending on raw material form of A. paniculata active substance.

Item Type: Article
Uncontrolled Keywords: Andrographis paniculata Ness;tablets;in vivo antimalarial activity;Plasmodium berghei; inhibition of parasite’s growth
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
Widyawaruyanti, Atyaty-w@ff.unair.ac.id
Asrory, MuhammadUNSPECIFIED
Ekasari, Wiwiedwiwied-e@ff.unair.ac.id
Setiawan, Dwidwisetyawan-90@ff.unair.ac.id
Radjaram, AchmadUNSPECIFIED
Tumewu, LidyaUNSPECIFIED
Hafid, Achmad Fuadachmadfuad@ff.unair.ac.id
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 21 Nov 2018 12:26
Last Modified: 21 Nov 2018 12:26
URI: http://repository.unair.ac.id/id/eprint/75680
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