Identification of Physical Interaction in Binary Systems of Acyclovir–Succinic Acid

Winanta 1, Agnes Nuniek and Setyawan, Dwi and Siswandono, Siswandono (2016) Identification of Physical Interaction in Binary Systems of Acyclovir–Succinic Acid. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 3 (1). pp. 27-31. ISSN 2406-9388

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Abstract

Acyclovir, a guanosine analogue antiviral drug with low solubility of water. Due to its poorsolubility and permeability, causes low oral bioavailability.Objective:The aim of this research is toinvestigatethe physical interaction in binary systems acyclovir-succinic acid (AS).Methods:Themsystemwas prepared by solvent evaporation method.Results:Thermogram Differential Scanning Calorimetryshowed endothermic peaks at 172.68 o C(ethanol) and 171.84 o C (methanol). The Powder X-RayDiffraction (PXRD) pattern of ASwasdifferent from pure component and physical mixtures. Furthermore,physical characterization showed the binary system of AS have unique crystal habit by polarizationmicroscope.Conclusion:New crystalline phase is formed from the interaction between acyclovir andsuccinic acid by solvent evaporation methodusing ethanol and methanol.Keywords:physical interaction, acyclovir, succinic acid, binary systems

Item Type: Article
Uncontrolled Keywords: physical interaction, acyclovir, succinic acid, binary systems
Subjects: R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
Winanta 1, Agnes NuniekUNSPECIFIED
Setyawan, DwiUNSPECIFIED
Siswandono, SiswandonoUNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 21 Nov 2018 15:26
Last Modified: 21 Nov 2018 15:26
URI: http://repository.unair.ac.id/id/eprint/75692
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