PHYSICAL INTERACTION STUDY OF IBUPROFEN-STEARIC ACID BINARY MIXTURE

Paramita, Diajeng Putri and Setyawan, Dwi and Isadiartuti, Dewi (2014) PHYSICAL INTERACTION STUDY OF IBUPROFEN-STEARIC ACID BINARY MIXTURE. In: International Conferences on Pharmaceutics & Pharmaceutical Sciences.

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Abstract

Ibuprofen is a non steroid anti-inflammatory drug (NSAID) derived from propionic acid [3]. It has low aqueous solubility but high permeability so it is classified into BCS (Biopharmaceutical Classification System) Class II [6]. High cohesivity and adhesivity cause ibuprofen has bad powder flow and also contributes to its high tendency for sticking to the punch. Granulation step is necessary in ibuprofen tableted dosage form manufacturing due bad compaction behaviour [9]. Thus, addition of appropriate excipients is hardly avoidable in order to improve powder properties in ibuprofen tableted dosage form formulation. Pharmaceutical dosage form manufacturing always involves heat and mechanical energy during the process [10]. This energy could induce interaction between drug and excipient molecules [10] as well as eutectic formation. Eutectics are intimate crystalline mixture of one compound in another and it has unique property in its lower melting temperature than that pure compound. Generally, eutectic interaction does not impact the pharmacological activity, but may contribute in alteration of the pharmaceutical properties. Unintentional eutectic formation in tableted dosage form development have been reported to lead to unwanted changes in the physical and/or chemical characteristics of the tablets [2]. Ibuprofen is a kind of drug that forms eutectic with some kind of excipients as reported in many studies [7, 11, 1]. It has been identified by DSC analysis that ibuprofen forms eutectic with stearic acid [7], one of most frequently used lubricant [4]. Therefore, further physical characterization was conducted in this study for better understanding of eutectic formation in ibuprofen-stearic acid binary system.

Item Type: Conference or Workshop Item (Paper)
Subjects: R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM/NIDN
Paramita, Diajeng PutriUNSPECIFIED
Setyawan, DwiUNSPECIFIED
Isadiartuti, DewiUNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 22 Nov 2018 13:32
Last Modified: 22 Nov 2018 13:32
URI: http://repository.unair.ac.id/id/eprint/75749
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