Solid State Characterization of Acyclovir-Nicotinamide Binary Systemsusing Solvent Evaporation Technique

Winantari, Agnes Nuniek and Setyawan, Dwi and Siswandono, Siswandono and Soewandhi, Sundani Nurono (2016) Solid State Characterization of Acyclovir-Nicotinamide Binary Systemsusing Solvent Evaporation Technique. Asian J. Pharm.Tech, 7 (1). pp. 33-36. ISSN 2231–5705

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Abstract

Objective of the study is to characterize acyclovir-nicotinamide binary systems (AN). Methods ofcocrystallization wassolvent evaporation in equimolar ratio between acyclovir and nicotinamide using ethanoland methanol. The binary systems were characterized by polarization microscope, Differential ScanningCalorimetry (DSC) and Powder X-Ray Diffraction (PXRD). Physical characterization showed that AN binarysystems have unique crystal habit in microscopic. A new endothermic peak appears at 123.69 C. The PXRDpatterns of AN binary systems after cocrystallization are different from pure components which specific peakwasfound on 2θ = 11.27 o (AN in ethanol); 21.05 o (AN in methanol).

Item Type: Article
Uncontrolled Keywords: Acyclovir, nicotinamide, binary systems, solvent evaporation, ethanol, methanol.
Subjects: R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
Winantari, Agnes NuniekUNSPECIFIED
Setyawan, DwiUNSPECIFIED
Siswandono, SiswandonoUNSPECIFIED
Soewandhi, Sundani NuronoUNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 22 Nov 2018 13:48
Last Modified: 22 Nov 2018 13:48
URI: http://repository.unair.ac.id/id/eprint/75751
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