Yuniarti, Wiwik Misaco and Yudaniayanti, Ira Sari and Triakoso, Nusdianto (2009) Gambaran Histopatologik Ginjal Tikus Putih (Rattus norvegicus) Pasca Ovariohisterektomi dengan Suplemen Kalsium Karbonat Dosis Tinggi. Medika Eksakta, 8 (1). pp. 31-38. ISSN 1411-6626

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Abstract

The aim of this research was to study the effect of high dose calcium carbonate as supplement to histopatological feature of renal rats (Rattus norvegicus) after ovaryohysterectomy. Ovaryohysterectomy was done to achived the lack of estrogen that equal with menopause in women. Total twenty female rats, strain Spraque dawley, 13 weeks old were used as experimental animals. After ovaryohysterectomy, they were randomized in four groups. P0 has been fed with standart food without calcium carbonate as supplement. P1, P2 and P3 were groups that each rat fed standart food with 75 mg/PO/day, 225 mg/PO/day and 450 mg/PO/day calcium carbonate respectively. The calcium carbonate supplement were given every morning during 42 days successively. The experimental animals were euthanized at 21 weeks old. The dexter kidneys were fixed in to 10% formalin for hystological observation using Haematoxylin-Eosin staining. The hystopatological feature of the kidneys were presented descriptively. The result showed the hypercellularity of glomerulus and necrosis of tubulus contortus proxymal in P0, but normal hystological feature were observed in P1. Contrarary, the sign of renal degeneration were clearly observed in P2 and P3. Sweling of glomerulus and necrosis of tubulus contortus proxymal were observed in P3. The conclusion of the research is the renal deterioration increased with augmentation of calcium carbonat given. Keywords: Ovaryohysterectomy, menopause, estrogen, calcium carbonate, kidney

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