PENGARUH pH, SUHU, DAN AKTIVATOR LOGAM TERHADAP AKTIVITAS ENZIM FIBRINOLITIK YANG DIHASILKAN Pseudomonas aeruginosa TS 6.4

SITI HALIMA HANUM, 051411131082 (2018) PENGARUH pH, SUHU, DAN AKTIVATOR LOGAM TERHADAP AKTIVITAS ENZIM FIBRINOLITIK YANG DIHASILKAN Pseudomonas aeruginosa TS 6.4. Skripsi thesis, Universitas Airlangga.

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Abstract

Fibrinolytic enzyme is discovered in some microorganisms, including Pseudomonas aeruginosa TS 6.4 which is isolated from sea cucumber (Paracaudina australis). Sea cucumbers have numerous pharmacological activities such as antithrombotic and antihyperlipidemic. In addition, Sticophus japonicus as one of the sea cucumbers species is proven containing fibrinolytic enzyme. Fibrinolytic enzyme activity is influenced by pH, temperature, activator, inhibitor, and substrate-enzyme concentration. This research aims to determine pH and optimum temperature of fibrinolytic enzyme activity from Pseudomonas aeruginosa TS 6.4. Optimum pH was reached at pH 5 – 6, while optimum temperature was attained at 50oC. The effect of metal activator CaCl2, MnCl2, MgCl2, ZnCl2, CoCl2 on fibrinolytic enzyme activity was also done to identify. The result showed that fibrinolytic activity of Pseudomonas aeruginosa TS 6. was affected by Ca2+, Mg2+, Mn2+, Zn2+, dan Co2+.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.KF. 17-18 Han p
Uncontrolled Keywords: Pseudomonas aeruginosa TS 6.4, fibrinolytic enzyme activity, pH, temperature, metal activator
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Kimia Farmasi
Creators:
CreatorsEmail
SITI HALIMA HANUM, 051411131082UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorAchmad Toto Poernomo, Dr., M.Si., Apt.UNSPECIFIED
ContributorSudjarwo MS, Prof. Dr., Apt.UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 13 Dec 2018 11:04
Last Modified: 13 Dec 2018 11:04
URI: http://repository.unair.ac.id/id/eprint/76682
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