VALIDASI METODE KROMATOGRAFI CAIR KINERJA TINGGI UNTUK INDIKASI STABILITAS RANITIDIN HCl DALAM SEDIAAN TABLET

AQMARINA AYU SEKARANI, 051411131156 (2018) VALIDASI METODE KROMATOGRAFI CAIR KINERJA TINGGI UNTUK INDIKASI STABILITAS RANITIDIN HCl DALAM SEDIAAN TABLET. Skripsi thesis, Universitas Airlangga.

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Abstract

A stability-indicating HPLC method has been developed and validated for the determination of ranitidine HCl in tablets. Chromatographic separation was achieved on a NH2 column using methanol-0.1 M aqueous ammonium acetate buffer pH 6.7 (85:15) as mobile phase. Ranitidine HCl was exposed to acid, alkali, oxidation, thermal and photolytic stress conditions. The stressed samples were analysed by the proposed method. Validation steps involved measurement of selectivity, linearity, accuracy, precision, robustness, and system suitability. The validated method has been demonstrated to be reliable for the determination of ranitidine HCl. The validation of this method indicated that it could be effectively used to monitor the stability of ranitidine HCl tablets.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.KF. 24-18 Sek v
Uncontrolled Keywords: Ranitidine hydrochloride, HPLC, Stability-indicating method, Validation
Subjects: R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi > Kimia Farmasi
Creators:
CreatorsEmail
AQMARINA AYU SEKARANI, 051411131156UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorM. Yuwono, Prof. Dr. rer. nat. H., MS., Apt.UNSPECIFIED
ContributorFebri Annuryanti, S.Farm., M.Sc., Apt.,UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 13 Dec 2018 11:55
Last Modified: 13 Dec 2018 11:55
URI: http://repository.unair.ac.id/id/eprint/76698
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