PENGARUH SUHU PADA REAKSI SINTESIS METIL FERULAT DENGAN METODE ULTRASONIK

RIAN PRATAMA PUTRA, 051111064 (2018) PENGARUH SUHU PADA REAKSI SINTESIS METIL FERULAT DENGAN METODE ULTRASONIK. Skripsi thesis, Universitas Airlangga.

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Abstract

In previous study showed that ferulic acid has an activities as an antiplatelet. But, because of its hydrophilic structure, its activities as antiplatelet is low. To increase its activities, it needs to increase its lipophilicity to be able to penetrate the cell membrane more easily. Lipophilicity of ferulic acid can be improved through structure modification into ester. In this study, ferulic acid was reacted with methanol to synthesized methyl ferulate using ultrasound. Ultrasound is reported able to shorten the reaction time and quickly gained the energy of activation needed for reaction. This study also conducted to determine the rate of reaction of ferulic acid esterification. The process was by making methyl ferulate and analyzed the remaining content of ferulic acid using TLC-densitometer. This reaction was carried out at temperature 55 °C and 65 °C. Based on the data, the esterification reaction of ferulic acid into methyl ferulate follow the second order of reaction with the rate constant (k) at 55 °C is 4x10-5 conc-1 minute-1 and the rate constant at 65 °C is 9x10-5 conc-1 minute-1. With the rate constant (k) from two different temperature found, the energy of activation (Ea) for this reaction is 17,9 kcal/mole. Since this reaction follow the second order of reaction, it means if the ferulic acid increase twice, it will also increase the rate of reaction of esterification four times than before.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.KF. 49- 18 Put p
Uncontrolled Keywords: ferulic acid, methanol, methyl ferulate, ultrasonic, rate of reaction.
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Kimia Farmasi
Creators:
CreatorsEmail
RIAN PRATAMA PUTRA, 051111064UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorJuni Ekowati, Dr., M.Si., Apt.UNSPECIFIED
ContributorNuzul Wahyuning Diyah, Dr., M.Si., Apt.UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 13 Dec 2018 18:33
Last Modified: 13 Dec 2018 18:33
URI: http://repository.unair.ac.id/id/eprint/76747
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