BIOAVAILABILITAS QUERCETIN SETELAH PEMBERIAN ORAL KOKRISTAL QUERCETIN–ASAM SUKSINAT PADA KELINCI

RANNY DWI KARTIKA SARI, 051411131075 (2018) BIOAVAILABILITAS QUERCETIN SETELAH PEMBERIAN ORAL KOKRISTAL QUERCETIN–ASAM SUKSINAT PADA KELINCI. Skripsi thesis, Universitas Airlangga.

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Abstract

Quercetin is a polyphenolic flavonoid with potential antioxidant activity which is belongs to the Biopharmaceutics Classification System (BCS) II, therefore modifying the quercetin formulation affect the bioavailability. In the present study, quercetin was modified by adding succinic acid as a coformer to the quercetin. The bioavailability profile of the 250mg/kg doses of quercetin was investigated in 6 rabbits. The animals were devided into quercetin alone group and quercetin-succinic acid cocrystal group. The concentration of quercetin in plasma were determined by a validated High Pressure Liquid Chromatography method. Bioavailability parameters including Tmax, Cmax and AUC0-480 were determined. In quercetin alone, the average value of Tmax, Cmax, AUC0-480 were 152,50 min, 0,59 ± 0,22 μg/mL, 454,12 ± 150,18 μg.min/mL, respectively. Tmax, Cmax and AUC0-480 of quercetin after the administration of quercetin-succinic acid cocrystal were 287,50 min, 0,74 ± 0,05 μg/mL, 439,49 ± 85,53 μg.min/mL, respectively. It is concluded that the quercetin-succinic acid cocrystallization does not increase the bioavailability of quercetin.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.FK. 24-18 Sar b
Uncontrolled Keywords: Quercetin, succinic acid, cocrystal, bioavailability, HPLC
Subjects: R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions
Divisions: 05. Fakultas Farmasi > Farmasi Klinis
Creators:
CreatorsNIM/NIDN
RANNY DWI KARTIKA SARI, 051411131075UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorChrismawan Ardianto, S.Farm., M.Sc., Ph.D., Apt.,UNSPECIFIED
ContributorDwi Setyawan, Dr. S.Si., M.Si., Apt.,UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 17 Dec 2018 15:00
Last Modified: 17 Dec 2018 15:00
URI: http://repository.unair.ac.id/id/eprint/76919
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