POTENSI TERAPI EKSTRAK KULIT MANGGIS (Garcinia mangostana) TERHADAP KERUSAKAN MUKOSA KOLON PADA MODEL HEWAN COBA MENCIT INFEKSI Shigella dysenteriae

Achmad Ilham Rizwani, 011511133026 (2018) POTENSI TERAPI EKSTRAK KULIT MANGGIS (Garcinia mangostana) TERHADAP KERUSAKAN MUKOSA KOLON PADA MODEL HEWAN COBA MENCIT INFEKSI Shigella dysenteriae. Skripsi thesis, Universitas Airlangga.

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Abstract

Background : Antibiotics treatment for bacillary dysentery due to Shigella dysenteriae infection have shown resistency. Mangosteen (Garcinia maangostana) rind have a therapy potency for Shigella dysenteriae infection due to its antibacterial, antiinflamation, and antioxidant activity. Objectives : Studying the potency of therapy with mangosteen (Garcinia mangostana) rind to mice’s colon mucose with Shigella dysenteriae infection. Methods : This research was an experimintal research, 30 mices was used which divided to 5 groups. The mices was infected with Shigella dysenteriae intraperitoneally, then azithromycin, aquadest, and 3 different doses of mangosteen (Garcinia mangostana) rind was given for each group for 5 days, which then the mice’s colon was collected and made into histopathology slide and its mucosal destruction was observed in 3 fields of view in each slide, 1 – 4 score was given acording to its mucosal destruction. Kruskal-Wallis test is used to analyzed the data and then Mann Whitney test also used for further analyze. Result : there was a healing effect obeserved when mangosteen (Garcinia mangostana) rind extract was given to the mice’s colon mucosal, 100 mg/Kg body mass dose of mangosteen (Garcinia mangostana) rind extract already given a positive effect on mice’s mucosal colon histopathological appearance, no difference observed between 3 dose given. Conclusion : Mangosteen (Garcinia mangostana) rind extract consumption gave healing appearance to destruction of colon mucosal wall of mices with Shigella dysenteriae infection at 100 mg/Kg body mass. Keyword : Mangosteen rind extract, Shigella dysenteriae, bacillary dysenteriae, Mice’s colon mucosal

Item Type: Thesis (Skripsi)
Additional Information: KKA KK FK PD 87/18 Riz p
Uncontrolled Keywords: Mangosteen rind extract, Shigella dysenteriae, bacillary dysenteriae, Mice’s colon mucosal
Subjects: R Medicine > RC Internal medicine > RC31-1245 Internal medicine
R Medicine > RM Therapeutics. Pharmacology
Divisions: 01. Fakultas Kedokteran
Creators:
CreatorsNIM/NIDN
Achmad Ilham Rizwani, 011511133026UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorArifa Mustika, Dr. dr., M.Si.UNSPECIFIED
ContributorLindawati Alimsardjono, dr., M.Kes, Sp.MK (K),UNSPECIFIED
Depositing User: sukartini sukartini
Date Deposited: 18 Dec 2018 12:55
Last Modified: 18 Dec 2018 12:55
URI: http://repository.unair.ac.id/id/eprint/76952
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