PENGARUH EKSTRAK AKAR PASAK BUMI (Eurycoma longifolia) TERHADAP HISTOPATOLOGI HEPAR TIKUS PUTIH (Rattus norvegicus) YANG DIPAPAR MONOSODIUM GLUTAMATE

NOVI AYU SEPTIANI, 061411131041 (2018) PENGARUH EKSTRAK AKAR PASAK BUMI (Eurycoma longifolia) TERHADAP HISTOPATOLOGI HEPAR TIKUS PUTIH (Rattus norvegicus) YANG DIPAPAR MONOSODIUM GLUTAMATE. Skripsi thesis, Universitas Airlangga.

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Abstract

This research aimed to know the effect of pasak bumi root extract (Eurycoma longifolia) on liver histopathology of rats (Rattus norvegicus) which were exposed to monosodium glutamate. Twenty-five male rats were divided into five treatment groups. The treatment was done for 30 days, each treatment consisted of K(-) as a negative control given 0.5% Na-CMC 2ml and 1ml aquadest, P0 was given 2ml aquadest and MSG 4g/kgBW/day. Meanwhile P1, P2 and P3 were given respectively 400, 600 and 900 mg/kgBW/day pasak bumi roots extract and MSG 400g/kgBW/day. The results showed that the means of hepatocyte cell underwent degeneration in K(-), P 0, P1, P2, and P3 were respectively 4.20 3.01. 19.60 2.53. 21.30 3.56. 13.10 1.67. 6.80 2.46 and hepatocyte cells underwent necrosis were 3.00 ± 0.00. 18,40 ± 1.34. 22.60 ± 219. 13.00 ± 1.54. 8.00 ± 1.41. Based on the results of the research, it could be concluded that pasak bumi root extract in rats could be used as a prevention of hepatocyte cell from degeneration and necrosis in rats exposed to MSG (p <0,05). Dose that can prevent hepatocyte cells from degeneration and necoses due to exposure to MSG was 900 mg/kgBW/day.

Item Type: Thesis (Skripsi)
Additional Information: KKC KK KH.171/18 Sep p
Uncontrolled Keywords: Pasak Bumi, Hepatocyte cells, Monosodium glutamate
Subjects: S Agriculture > SF Animal culture > SF405.5-407 Laboratory animals
Divisions: 06. Fakultas Kedokteran Hewan > Ilmu Kedokteran Hewan Dasar
Creators:
CreatorsNIM/NIDN
NOVI AYU SEPTIANI, 061411131041UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorSuzanita Utama, drh., M.Phil., Ph.D.UNSPECIFIED
ContributorSunaryo Hadi Warsito, drh., M.P.UNSPECIFIED
Depositing User: mrs hoeroestijati beta
Date Deposited: 19 Dec 2018 17:52
Last Modified: 19 Dec 2018 17:52
URI: http://repository.unair.ac.id/id/eprint/77075
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