AYU RATNASARI, 051615153021 (2018) ANALISIS PENGGUNAAN METILPREDNISOLON MEGADOSIS TERHADAP PENURUNAN KADAR OSTEOCALCIN PADA PASIEN LUPUS NEFRITIS ANAK (Penelitian Dilaksanakan di Divisi Nefrologi SMF Ilmu Kesehatan Anak RSUD Dr. Soetomo Surabaya). Thesis thesis, Universitas Airlangga.
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Abstract
Background: Lupus nephritis (LN) is a severe lupus and life-threatening manifestation of SLE. LN should be treated aggressively with megadose methylprednisolone which may cause suppression of bone formation and decrease osteocalcin levels. Objectives: To analyze the effect of megadose methylprednisolone treatment (three days administration of 10-30 mg/kg/days methylprednisolone pulse) on osteocalcin levels in pediatric patients with lupus nephritis. Method: A prospective observational method was conducted in this study. It was approved by the Ethics Committee of Dr. Soetomo Teaching Hospital Surabaya. Data was collected from July to September 2018. Osteocalcin levels were measured at day 1 (before patients received methylprednisolone pulse treatment) and day 4 (after the 3-day of methylprednisolone pulse treatment). Blood samples were obtained in the morning at 06.00- 10.00 am. The collected data were analyzed statistically by paired t-test. Results: Seventeen patients were recruited in this study and four patients were observed again in the next cycle. Therefore, 21 sample were analyzed in this study. They were 7-16 years old (53% were boys). Forty-two percent patients were in 2nd cycle of methylprednisolone pulse therapy. There were no correlation between prednisone and calcium supplementation vs osteocalcin levels prior to methylprednisolone pulse (p > 0,05). The baseline of osteocalcin levels in majority patients were lower than reference value. After 3 days of methylprednisolone pulse therapy, osteocalcin levels decreased 51.89% from 23.197 ± 10.108 ng/ml to 11.159 ± 9.024 ng/ml (p < 0,01). Conclusion: Megadose methylprednisolone therapy can cause an immediate decrease in osteocalcin levels. Further study is important to find out how long the suppression occurs.
| Item Type: | Thesis (Thesis) | |||||||||
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| Additional Information: | KKB KK-2 TFK. 30-18 Rat a | |||||||||
| Uncontrolled Keywords: | Osteocalcin, megadose methylprednisolone, glucocorticoid pulse, lupus nephritis, children | |||||||||
| Subjects: | R Medicine > RJ Pediatrics R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions |
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| Divisions: | 05. Fakultas Farmasi > Farmasi Klinis | |||||||||
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| Depositing User: | Tatik Poedjijarti | |||||||||
| Date Deposited: | 20 Dec 2018 10:42 | |||||||||
| Last Modified: | 20 Dec 2018 10:42 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/77099 | |||||||||
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