ANALISIS RASIO sRANkL/OPG TERKAIT PERUBAHAN BONE TURNOVER PADA PASIEN EPILEPSI YANG MENDAPAT TERAPI KOMBINASI VALPROAT-FENITOIN JANGKA PANJANG (Penelitian dilakukan di Poli Saraf Instalasi Rawat Jalan RSU Haji Surabaya)

NAILI USWATUN HASANAH, 051615153025 (2018) ANALISIS RASIO sRANkL/OPG TERKAIT PERUBAHAN BONE TURNOVER PADA PASIEN EPILEPSI YANG MENDAPAT TERAPI KOMBINASI VALPROAT-FENITOIN JANGKA PANJANG (Penelitian dilakukan di Poli Saraf Instalasi Rawat Jalan RSU Haji Surabaya). Thesis thesis, Universitas Airlangga.

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Abstract

Objective: Epilepsy is a neurological disorder that characterized by electroencephalographic changes accompanying seizures. The main therapy for epilepsy is an Anti-Epileptic Drugs (AEDs) for a long time administration. Long-term use of AEDs induce hepatic enzyme (i.e. phenytoin) and valproate has adverse side effects on bones. Fractures risk in epilepsy patients increased two to six fold. AEDs alter bone metabolism by decreasing vitamin D levels and other mechanisms such as increasing bone biomarkers like RANkL and OPG. RANkL and OPG are main regulators of bone resorption. Increased RANkL / OPG ratio cause an increase the osteoclastogenesis and bone resorption. This study was aimed to analyze the ratio of sRANkL / OPG in epileptic patients who received long-term therapy of valproate – phenytoin combination. Method: The method of this study was an observational prospective study. The study was conducted at Neurology Department Haji General Hospital Surabaya. The inclusion criteria were all epileptic patients aged 18-55 years in the period July -September 2018, received OAE therapy ≥ 6 months. The exclusion criteria were patients with a history of thyroid disorders, chronic kidney disorders, drug use that affects bone turnover, vitamin D or calcium supplements use and menopause patients. The data obtained were serum levels of sRANkL and OPG in pg / ml units, then these data will be used as a ratio. Data were analyzed statistically. Result: The result of this study; the ratio of sRANkL / OPG in epilepsy patients receiving combination therapy (n = 9) was 4.827 ± 1.461 compared to the single group valproate (n = 11) 4.623 ± 0.785 and the single phenytoin group (n = 10) 3, 664 ± 0.871. Different test between these 3 groups has a significant difference with p = 0.048. Conclusion: There is an increase in the sRANKL / OPG ratio in epilepsy patients who received long-term valproate-phenytoin combination therapy.

Item Type: Thesis (Thesis)
Additional Information: KKB KK-2 TFK. 36-18 Has a
Uncontrolled Keywords: epilepsy patients, bone, anti-epileptic drug, long-term therapy
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmasi Klinis
Creators:
CreatorsNIM/NIDN
NAILI USWATUN HASANAH, 051615153025UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorDidik Hasmono, Drs., MS., AptUNSPECIFIED
ContributorDiah Hari Soeryaningtias, dr., Sp. SUNSPECIFIED
ContributorDewi Ramdani, Dra., M. Farm.Klin., AptUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 20 Dec 2018 11:37
Last Modified: 20 Dec 2018 11:37
URI: http://repository.unair.ac.id/id/eprint/77118
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