PENGARUH JUMLAH KITOSAN TERHADAP LAJU PELEPASAN ANDROGRAFOLID DARI MIKROPARTIKEL ANDROGRAFOLID-KITOSAN (Dibuat dengan metode gelasi ionik-pengeringan beku)

WAFIQOH AMIRAH, 051411131053 (2018) PENGARUH JUMLAH KITOSAN TERHADAP LAJU PELEPASAN ANDROGRAFOLID DARI MIKROPARTIKEL ANDROGRAFOLID-KITOSAN (Dibuat dengan metode gelasi ionik-pengeringan beku). Skripsi thesis, Universitas Airlangga.

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Abstract

Andrographolide has low solubility and short half life (t1/2 = 1,5-2 hours). Therefore andrographolide has a low bioavailability. Andrographolide-chitosan microparticles was expected to improve dissolution and further could increase bioavailability of andrographolide. The objective of this research was to investigate the effect of chitosan concentration on infrared spectrum and in vitro release of andrographolide from microparticles. Microparticles were prepared by ionic gelation and used sodium tripolyphosphate (TPP) as cross linker and dried by freeze drying method. The chitosan concentration that used in this research were 0,5% (L0,5), 0,625% (L0,75) and 0,75% (L0,75). Infrared spectrum of microparticles shows that there was ionic bonding between chitosan and TPP. The model of release kinetics suitable for andrographolide-chitosan microparticles system was The Higuchi model. Release rate of microparticles in phosphate buffer pH 7 ± 0,05 are higher than andrographolide as control. It show that andrographolide-chitosan microparticles are able to enhance dissolution rate of andrographolide.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F. 17-18 Ami p
Uncontrolled Keywords: andrographolide, chitosan, microparticle, freeze drying, ionic gelation
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
WAFIQOH AMIRAH, 051411131053UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorRetno Sari, Dr., M. Sc., Apt.UNSPECIFIED
ContributorHelmy Yusuf, S.Si., M.Sc., P.h.D.,AptUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 27 Dec 2018 05:39
Last Modified: 27 Dec 2018 05:39
URI: http://repository.unair.ac.id/id/eprint/77214
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