KARAKTERISASI KOMPLEKS INKLUSI ASAM p-METOKSISINAMAT (APMS) - HIDROKSIPROPIL β -SIKLODEKSTRIN (HPβCD) (Dibuat dengan Metode Freeze Drying)

RADINAL SHAFAR HERDIANTO, 051411131174 (2018) KARAKTERISASI KOMPLEKS INKLUSI ASAM p-METOKSISINAMAT (APMS) - HIDROKSIPROPIL β -SIKLODEKSTRIN (HPβCD) (Dibuat dengan Metode Freeze Drying). Skripsi thesis, Universitas Airlangga.

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Abstract

Para-methoxycinnamic acid (pMCA) is a major substance synthetized from Kaempferia galanga L. pMCA has an analgesic effect but, it has a very low solubility in water (0,712 mg/ml). Therefore, to improve the solubility of pMCA, pMCA was complexed with hydroxypropil β –cyclodextrin (HPβCD). The purpose of this study was to characterize pMCA- HPβCD inclusion complex prepared in 1:1 molar ratio with freeze drying method. The inclusion complex was characterized by X-Ray Diffractometer (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and Differential Thermal Analysis (DTA) compared to pMCA, HPβCD, and physical mixture. The diffractogram of inclusion complex pMCA- HPβCD showed the disappearance of the pMCA spectral lines. FTIR spectra showed that the spectra of aromatic group from the pMCA was loss. The DTA study showed the endothermic peak was decreased the intensity and shift to different temperature. The inclusion complexes are shown to have different characteristics when compared with the single compound of pMCA, HPβCD, and the physical mixture of pMCA- HPβCD. These changing of characteristics proved that inclusion complex was formed.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F. 36-18 Her k
Uncontrolled Keywords: p-methoxycinnamic acid, hydroxypropil β –cyclodextrin, inclusion complex, freeze drying method, characterizaton
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
RADINAL SHAFAR HERDIANTO, 051411131174UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorDewi Isadiartuti, Dr., M.Si., Apt.UNSPECIFIED
ContributorJuni Ekowati, Dr., M.Si., Apt.UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 28 Dec 2018 02:49
Last Modified: 28 Dec 2018 02:49
URI: http://repository.unair.ac.id/id/eprint/77279
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