FORMULASI DAN KARAKTERISASI FISIKOKIMIA LIPOSOM PRIMAKUIN DAN LIPOSOM KLOROKUIN UNTUK PENGEMBANGAN OBAT TERAPI MALARIA

SITI MARIA ZAHRO, 051411131170 (2018) FORMULASI DAN KARAKTERISASI FISIKOKIMIA LIPOSOM PRIMAKUIN DAN LIPOSOM KLOROKUIN UNTUK PENGEMBANGAN OBAT TERAPI MALARIA. Skripsi thesis, Universitas Airlangga.

[img] Text (Abstrak)
FF.F. 43-18 Zah f Abstrak.pdf

Download (137kB)
[img] Text (Fulltext)
FF.F. 43-18 Zah f.pdf
Restricted to Registered users only until 28 December 2021.

Download (2MB) | Request a copy
Official URL: http://lib.unair.ac.id

Abstract

Malaria is a topical disease that is caused by the Plasmodium parasite which is transmitted through the bite of infected Anopheles mosquitos. Phases of malaria divided to hepatic phase and erythrocytic phase. Primaquine has been known as the only effective therapy for hepatic stage of malaria. However the severe toxicity of primaquine causing hemolysis has limited its use in clinical therapy. Its has been reported that combination therapy of primaquine and chloroquine that is effective for erythrocytic stage of malaria, could increase therapeutics efficacy as well as reduce primaquine toxicity. This study aimed to determine optimal temperature and time incubation, and ratio drug:lipid in liposomal primaquine and liposomal chloroquine for develop liposomal combination primaquine and chloroquine. Liposome was composed of HSPC, cholesterol, and DSPE mPEG2000 at a molar ratio 55:40:5, and prepared by a transmembrane pH gradient method with different time, different temperature, and ratio drug:lipid. nd used HSPC and DSPE-mPEG2000. Liposomes was made were evaluate their particle size, ζ potential, and efficiency encapsulation. The results showed that increasing of temperature incubation would increase efficiency encapsulation. In liposomal chloroquine showed that increasing of drug:lipid ratio would increase efficiency encapsulation. This result contrast with liposomal primaquine.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK=2 FF.F. 43-18 Zah f
Uncontrolled Keywords: Malaria, primaquine, chloroquine, liposomes, physicochemical Characterization, formulation.
Subjects: R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
SITI MARIA ZAHRO, 051411131170UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorEsti Hendradi, Dra., M.Si., Ph.D., AptUNSPECIFIED
ContributorAndang Miatmoko, Ph.D., AptUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 28 Dec 2018 03:45
Last Modified: 28 Dec 2018 03:45
URI: http://repository.unair.ac.id/id/eprint/77293
Sosial Share:

Actions (login required)

View Item View Item