EFEKTIVITAS ANTI-AGING CoQ10 DALAM SISTEM SOLID LIPID NANOPARTICLE (SLN)

ASRI NURAHMI SAKINAH, 051411131191 (2018) EFEKTIVITAS ANTI-AGING CoQ10 DALAM SISTEM SOLID LIPID NANOPARTICLE (SLN). Skripsi thesis, Universitas Airlangga.

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Abstract

Coenzyme Q10 (CoQ10) is a lipid-soluble and chemically unstable compound. Solid Lipid Nanoparticles (SLN) is an alternative drug carrier system that can be used to improve stability of CoQ10. CoQ10 has been reported to have anti-aging effect on skin. The aim of this study is to evaluate the skin anti-aging effect of CoQ10-loaded SLN (SLN CoQ10). SLN was formulated by a high shear homogenization method. The formulation of SLN dispersion consisted of 20% lipid (Cetyl Palmitate), 20% surfactant (Tween 80 and Span 80), 10% cosurfactant (Poloxamer 188), and acetic buffer. SLN CoQ10 was charaterized for pH, particle size, polydispersity index, and thermal analysis. In vivo skin hydration, wrinkle, spot, pore and collagen intensity studies were performed on 19 female volunteers aged 30−40 years. In the in vivo study, treatment with 1% CoQ10-loaded SLN for 8 weeks significantly reduced the percentage of wrinkle, spot, and pore size; and significantly increased the collagen intensity.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F. 44-18 Sak e
Uncontrolled Keywords: Solid lipid nanoparticles, coenzyme Q10, in vivo study, anti-aging
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
ASRI NURAHMI SAKINAH, 051411131191UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorNoorma Rosita, Dr., M.Si., Apt.UNSPECIFIED
ContributorWidji Soeratri, Prof. Dr., DEA, Apt.UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 28 Dec 2018 04:02
Last Modified: 28 Dec 2018 04:02
URI: http://repository.unair.ac.id/id/eprint/77295
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